Hypotaurine dehydrogenase

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In enzymology, a hypotaurine dehydrogenase (EC 1.8.1.3) is an enzyme that catalyzes the chemical reaction

hypotaurine + H₂O + NAD⁺ taurine + NADH + H⁺

The 3 substrates of this enzyme are hypotaurine, H₂O, and NAD⁺, whereas its 3 products are taurine, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hypotaurine:NAD+ oxidoreductase. This enzyme participates in taurine and hypotaurine metabolism. It has 2 cofactors: heme, and Molybdenum.

[edit] References

• IUBMB entry for 1.8.1.3
• BRENDA references for 1.8.1.3 (Recommended.)
• PubMed references for 1.8.1.3
• PubMed Central references for 1.8.1.3
• Google Scholar references for 1.8.1.3
• Sumizu K (1962). "Oxidation of hypotaurine in rat liver". Biochim. Biophys. Acta 63: 210–212. doi:10.1016/0006-3002(62)90357-8. 

[edit] External links

The CAS registry number for this enzyme class is 37256-46-5.

• IUBMB entry for 1.8.1.3

• KEGG entry for 1.8.1.3

• BRENDA entry for 1.8.1.3

• NiceZyme view of 1.8.1.3

• EC2PDB: PDB structures for 1.8.1.3

• PRIAM entry for 1.8.1.3

• PUMA2 entry for 1.8.1.3

• IntEnz: Integrated Enzyme entry for 1.8.1.3

• MetaCyc entry for 1.8.1.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047822: hypotaurine dehydrogenase

• AMIGO entry for GO code 0047822: hypotaurine dehydrogenase