Hypocretin (orexin) receptor 2

From Wikipedia, the free encyclopedia

Identifiers

External IDs

OMIM: 602393 MGI: 2680765 HomoloGene: 1168

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • receptor activity • neuropeptide receptor activity • orexin receptor activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• signal transduction • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) • neuropeptide signaling pathway • synaptic transmission • feeding behavior

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001526 (mRNA)
NP_001517 (protein)

NM_198962 (mRNA)
NP_945200 (protein)

Location

Chr 6: 55.15 - 55.26 Mb

Chr 9: 76.01 - 76.11 Mb

Pubmed search

[1]

[2]

Hypocretin (orexin) receptor 2, also known as HCRTR2, is a human gene.^[1]

HCRTR2 is a G-protein coupled receptor expressed exclusively in the brain. It has 64% identity with HCRTR1. HCRTR2 binds both orexin A and orexin B neuropeptides. HCRTR2 is involved in the central feedback mechanism that regulates feeding behaviour.^[1]

[edit] See also

Orexin receptor

[edit] References

^ ^a ^b Entrez Gene: HCRTR2 hypocretin (orexin) receptor 2.

[edit] Further reading

Flier JS, Maratos-Flier E (1998). "Obesity and the hypothalamus: novel peptides for new pathways.". Cell 92 (4): 437-40. PMID 9491885.
Willie JT, Chemelli RM, Sinton CM, Yanagisawa M (2001). "To eat or to sleep? Orexin in the regulation of feeding and wakefulness.". Annu. Rev. Neurosci. 24: 429-58. doi:10.1146/annurev.neuro.24.1.429. PMID 11283317.
Hungs M, Mignot E (2001). "Hypocretin/orexin, sleep and narcolepsy.". Bioessays 23 (5): 397-408. doi:10.1002/bies.1058. PMID 11340621.
de Lecea L, Kilduff TS, Peyron C, et al. (1998). "The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 322-7. PMID 9419374.
Sakurai T, Amemiya A, Ishii M, et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.". Cell 92 (4): 573-85. PMID 9491897.
Sakurai T, Amemiya A, Ishii M, et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.". Cell 92 (5): 1 page following 696. PMID 9527442.
Peyron C, Faraco J, Rogers W, et al. (2000). "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.". Nat. Med. 6 (9): 991-7. doi:10.1038/79690. PMID 10973318.
Wright GJ, Puklavec MJ, Willis AC, et al. (2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.". Immunity 13 (2): 233-42. PMID 10981966.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Mazzocchi G, Malendowicz LK, Gottardo L, et al. (2001). "Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade.". J. Clin. Endocrinol. Metab. 86 (2): 778-82. PMID 11158046.
Blanco M, López M, García-Caballero T, et al. (2001). "Cellular localization of orexin receptors in human pituitary.". J. Clin. Endocrinol. Metab. 86 (4): 1616-9. PMID 11297593.
Blanco M, López M, GarcIa-Caballero T, et al. (2001). "Cellular localization of orexin receptors in human pituitary.". J. Clin. Endocrinol. Metab. 86 (7): 1616-9. PMID 11443222.
Karteris E, Randeva HS, Grammatopoulos DK, et al. (2001). "Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals.". J. Clin. Endocrinol. Metab. 86 (9): 4512-9. PMID 11549701.
Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW (2001). "Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis.". J. Clin. Endocrinol. Metab. 86 (10): 4808-13. PMID 11600545.
Olafsdóttir BR, Rye DB, Scammell TE, et al. (2002). "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.". Neurology 57 (10): 1896-9. PMID 11723285.
Blanco M, García-Caballero T, Fraga M, et al. (2002). "Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas.". Regul. Pept. 104 (1-3): 161-5. PMID 11830291.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened