Hyperhomocysteinemia
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| Hyperhomocysteinemia Classification and external resources |
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| Homocysteine | |
| DiseasesDB | 29853 |
| eMedicine | neuro/578 |
Hyperhomocysteinemia is a medical condition characterized by an abnormally large level of homocysteine in the blood.
As a consequence of the biochemical reactions in which homocysteine is involved, deficiencies of the vitamins folic acid, pyridoxine (B6), or B12 can lead to high homocysteine levels.[1] Supplementation with pyridoxine, folic acid, B12 or trimethylglycine (betaine) reduces the concentration of homocysteine in the bloodstream.[2]
Normal fasting homocysteine plasma levels are between 5,0 and 15,9 mmol/l.
[edit] See also
Hyperhomocysteinemia is a risk factor for coronary artery disease and in cases of young myocardial infarction the level is found to be elevated.
[edit] References
- ^ Miller JW, Nadeau MR, Smith D, Selhub J (1994). "Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats". American Journal of Clinical Nutrition 59: 1033–1039. PMID 8172087.
- ^ van Guldener C, Stehouwer CD (2001). "Homocysteine-lowering treatment: an overview". Expert Opinion on Pharmacotherapy 2 (9): 1449–1460. doi:. PMID 11585023.
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