Hydroxyphenylpyruvate reductase

From Wikipedia, the free encyclopedia

In enzymology, a hydroxyphenylpyruvate reductase (EC 1.1.1.237) is an enzyme that catalyzes the chemical reaction

3-(4-hydroxyphenyl)lactate + NAD⁺ 3-(4-hydroxyphenyl)pyruvate + NADH + H⁺

Thus, the two substrates of this enzyme are 3-(4-hydroxyphenyl)lactate and NAD⁺, whereas its 3 products are 3-(4-hydroxyphenyl)pyruvate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxyphenyllactate:NAD+ oxidoreductase. This enzyme is also called HPRP. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

[edit] References

• IUBMB entry for 1.1.1.237
• BRENDA references for 1.1.1.237 (Recommended.)
• PubMed references for 1.1.1.237
• PubMed Central references for 1.1.1.237
• Google Scholar references for 1.1.1.237
• Petersen M and Alfermann AW (1988). "Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase". Z. Naturforsch. C: Biosci. 43: 501–504. 

[edit] External links

The CAS registry number for this enzyme class is 117590-77-9.

• IUBMB entry for 1.1.1.237

• KEGG entry for 1.1.1.237

• BRENDA entry for 1.1.1.237

• NiceZyme view of 1.1.1.237

• EC2PDB: PDB structures for 1.1.1.237

• PRIAM entry for 1.1.1.237

• PUMA2 entry for 1.1.1.237

• IntEnz: Integrated Enzyme entry for 1.1.1.237

• MetaCyc entry for 1.1.1.237

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047995: hydroxyphenylpyruvate reductase

• AMIGO entry for GO code 0047995: hydroxyphenylpyruvate reductase