Hydroxymethylpyrimidine kinase

From Wikipedia, the free encyclopedia

In enzymology, a hydroxymethylpyrimidine kinase (EC 2.7.1.49) is an enzyme that catalyzes the chemical reaction

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine

Thus, the two substrates of this enzyme are ATP and 4-amino-5-hydroxymethyl-2-methylpyrimidine, whereas its two products are ADP and 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase. This enzyme is also called hydroxymethylpyrimidine kinase (phosphorylating). This enzyme participates in thiamine metabolism.

[edit] References

• IUBMB entry for 2.7.1.49
• BRENDA references for 2.7.1.49 (Recommended.)
• PubMed references for 2.7.1.49
• PubMed Central references for 2.7.1.49
• Google Scholar references for 2.7.1.49
• Lewin LM and Brown GM (1961). "The biosynthesis of thiamine. III. Mechanism of enzymatic formation of the pyrophosphate ester of 2-methyl-4-amino-5-hydroxymethylpyrimidine". J. Biol. Chem. 236: 2768–2771. 

[edit] External links

The CAS registry number for this enzyme class is 9026-55-5.

• IUBMB entry for 2.7.1.49

• KEGG entry for 2.7.1.49

• BRENDA entry for 2.7.1.49

• NiceZyme view of 2.7.1.49

• EC2PDB: PDB structures for 2.7.1.49

• PRIAM entry for 2.7.1.49

• PUMA2 entry for 2.7.1.49

• IntEnz: Integrated Enzyme entry for 2.7.1.49

• MetaCyc entry for 2.7.1.49

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008902: hydroxymethylpyrimidine kinase

• AMIGO entry for GO code 0008902: hydroxymethylpyrimidine kinase