Hydroxymethylglutaryl-CoA synthase

From Wikipedia, the free encyclopedia

In enzymology, a hydroxymethylglutaryl-CoA synthase (EC 2.3.3.10) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + H₂O + acetoacetyl-CoA (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

The 3 substrates of this enzyme are acetyl-CoA, H₂O, and acetoacetyl-CoA, whereas its two products are (S)-3-hydroxy-3-methylglutaryl-CoA and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming). Other names in common use include (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase, (CoA-acetylating), 3-hydroxy-3-methylglutaryl CoA synthetase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A synthetase, 3-hydroxy-3-methylglutaryl-CoA synthase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase, beta-hydroxy-beta-methylglutaryl-CoA synthase, HMG-CoA synthase, acetoacetyl coenzyme A transacetase, hydroxymethylglutaryl coenzyme A synthase, and hydroxymethylglutaryl coenzyme A-condensing enzyme. This enzyme participates in 3 metabolic pathways: synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, and butanoate metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1XPK, 1XPL, 1XPM, and 2P8U.

[edit] References

• IUBMB entry for 2.3.3.10
• BRENDA references for 2.3.3.10 (Recommended.)
• PubMed references for 2.3.3.10
• PubMed Central references for 2.3.3.10
• Google Scholar references for 2.3.3.10
• RUDNEY H (1957). "The biosynthesis of beta-hydroxy-beta-methylglutaric acid". J. Biol. Chem. 227: 363–77. PMID 13449080. 

[edit] External links

The CAS registry number for this enzyme class is 9027-44-5.

• IUBMB entry for 2.3.3.10

• KEGG entry for 2.3.3.10

• BRENDA entry for 2.3.3.10

• NiceZyme view of 2.3.3.10

• EC2PDB: PDB structures for 2.3.3.10

• PRIAM entry for 2.3.3.10

• PUMA2 entry for 2.3.3.10

• IntEnz: Integrated Enzyme entry for 2.3.3.10

• MetaCyc entry for 2.3.3.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004421: hydroxymethylglutaryl-CoA synthase

• AMIGO entry for GO code 0004421: hydroxymethylglutaryl-CoA synthase