Hydroxymandelonitrile lyase

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In enzymology, a hydroxymandelonitrile lyase (EC 4.1.2.11) is an enzyme that catalyzes the chemical reaction

(S)-4-hydroxymandelonitrile $\rightleftharpoons$ cyanide + 4-hydroxybenzaldehyde

Hence, this enzyme has one substrate, (S)-4-hydroxymandelonitrile, and two products, cyanide and 4-hydroxybenzaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming). Other names in common use include hydroxynitrile lyase, oxynitrilase, Sorghum hydroxynitrile lyase, and (S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase. This enzyme participates in cyanoamino acid metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GXS.

[edit] References

IUBMB entry for 4.1.2.11
BRENDA references for 4.1.2.11 (Recommended.)
PubMed references for 4.1.2.11
PubMed Central references for 4.1.2.11
Google Scholar references for 4.1.2.11
AJ (2006). "Population pharmacokinetics of liposomal amphotericin B in pediatric patients with malignant diseases". Antimicrob. Agents. Chemother. 50: 935–42. doi:10.1128/AAC.50.3.935-942.2006. PMID 16495254.
Seely MK, Criddle RS, Conn EE (1966). "The metabolism of aromatic compounds in higher plants. 8. On the requirement of hydroxynitrile lyase for flavin". J. Biol. Chem. 241: 4457–62. PMID 5922969.