Hydroxylamine reductase (NADH)

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In enzymology, a hydroxylamine reductase (NADH) (EC 1.7.1.10) is an enzyme that catalyzes the chemical reaction

NH₃ + NAD⁺ + H₂O $\rightleftharpoons$ hydroxylamine + NADH + H⁺

The 3 substrates of this enzyme are NH₃, NAD⁺, and H₂O, whereas its 3 products are hydroxylamine, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ammonium:NAD+ oxidoreductase. Other names in common use include hydroxylamine reductase, ammonium dehydrogenase, NADH-hydroxylamine reductase, N-hydroxy amine reductase, hydroxylamine reductase (NADH2), and NADH2:hydroxylamine oxidoreductase. This enzyme participates in nitrogen metabolism.

[edit] References

IUBMB entry for 1.7.1.10
BRENDA references for 1.7.1.10 (Recommended.)
PubMed references for 1.7.1.10
PubMed Central references for 1.7.1.10
Google Scholar references for 1.7.1.10
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Bernheim ML, Hochstein P (1968). "Reduction of hydroxylamine by rat liver mitochondria". Arch. Biochem. Biophys. 124: 436–42. doi:10.1016/0003-9861(68)90349-4. PMID 4298499.
Wang R and Nicholas DJD (1986). "Some properties of nitrite and hydroxylamine reductases from Derxia gummosa". Phytochemistry 25: 2463–2469. doi:10.1016/S0031-9422(00)84489-1.