Hydroxylamine oxidase

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In enzymology, a hydroxylamine oxidase (EC 1.7.3.4) is an enzyme that catalyzes the chemical reaction

hydroxylamine + O₂ $\rightleftharpoons$ nitrite + H₂O

Thus, the two substrates of this enzyme are hydroxylamine and O₂, whereas its two products are nitrite and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with oxygen as acceptor. The systematic name of this enzyme class is hydroxylamine:oxygen oxidoreductase. Other names in common use include HAO and hydroxylamine oxidoreductase. This enzyme participates in nitrogen metabolism. It employs one cofactor, heme.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1FGJ.

[edit] References

IUBMB entry for 1.7.3.4
BRENDA references for 1.7.3.4 (Recommended.)
PubMed references for 1.7.3.4
PubMed Central references for 1.7.3.4
Google Scholar references for 1.7.3.4
Hooper AB, Balny C (1982). "Reaction of oxygen with hydroxylamine oxidoreductase of Nitrosomonas: fast kinetics". FEBS. Lett. 144: 299–303. doi:10.1016/0014-5793(82)80658-3. PMID 7117545.
Lipscomb JD, Hooper AB (1982). "Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 1. Electron paramagnetic resonance spectroscopy". Biochemistry. 21: 3965–72. doi:10.1021/bi00260a010. PMID 6289867.
Rees MK (1968). "Studies of the hydroxylamine metabolism of Nitrosomonas europaea. I Purification of hydroxylamine oxidase". Biochemistry. 7: 353–66. doi:10.1021/bi00841a045. PMID 5758552.