Hydroxyacylglutathione hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a Hydroxyacylglutathione hydrolase (EC 3.1.2.6) is an enzyme that catalyzes the chemical reaction

(R)-S-lactoylglutathione + water glutathione + a 2-hydroxy carboxylate

Hence, this enzyme has two substrate, (R)-S-lactoylglutathione and water, and two products, glutathione and a 2-hydroxy carboxylate. With the common substrate methylglyoxal, the product is D-lactate.^[1]

This enzyme belongs to the family of hydrolases, specifically the class of thioester lyases. This enzyme is commonly known asglyoxylase II. This enzyme participates in pyruvate metabolism.

[edit] References

• IUBMB entry for 3.1.2.6
• BRENDA references for 3.1.2.6 (Recommended.)
• PubMed references for 3.1.2.6
• PubMed Central references for 3.1.2.6
• Google Scholar references for 3.1.2.6
• Ball JC, Vander Jagt DL (1979). "Purification of S-2-hydroxyacylglutathione hydrolase (glyoxalase II) from rat erythrocytes". Anal. Biochem. 98 (2): 472–7. PMID 496013. 

[edit] External links

• IUBMB entry for 3.1.2.6

• KEGG entry for 3.1.2.6

• BRENDA entry for 3.1.2.6

• NiceZyme view of 3.1.2.6

• EC2PDB: PDB structures for 3.1.2.6

• PRIAM entry for 3.1.2.6

• PUMA2 entry for 3.1.2.6

• IntEnz: Integrated Enzyme entry for 3.1.2.6

• MetaCyc entry for 3.1.2.6

• Atomic-resolution structures of enzymes belonging to this class