Hydroxyacid-oxoacid transhydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxybutanoate + 2-oxoglutarate acetoacetate + (R)-2-hydroxyglutarate

Thus, the two substrates of this enzyme are (S)-3-hydroxybutanoate and 2-oxoglutarate, whereas its two products are acetoacetate and (R)-2-hydroxyglutarate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase. This enzyme is also called transhydrogenase, hydroxy acid-oxo acid.

[edit] References

• IUBMB entry for 1.1.99.24
• BRENDA references for 1.1.99.24 (Recommended.)
• PubMed references for 1.1.99.24
• PubMed Central references for 1.1.99.24
• Google Scholar references for 1.1.99.24
• Kaufman EE, Nelson T, Fales HM, Levin DM (1988). "Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria". J. Biol. Chem. 263: 16872–9. PMID 3182820. 

[edit] External links

The CAS registry number for this enzyme class is 117698-31-4.

• IUBMB entry for 1.1.99.24

• KEGG entry for 1.1.99.24

• BRENDA entry for 1.1.99.24

• NiceZyme view of 1.1.99.24

• EC2PDB: PDB structures for 1.1.99.24

• PRIAM entry for 1.1.99.24

• PUMA2 entry for 1.1.99.24

• IntEnz: Integrated Enzyme entry for 1.1.99.24

• MetaCyc entry for 1.1.99.24

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047988: hydroxyacid-oxoacid transhydrogenase

• AMIGO entry for GO code 0047988: hydroxyacid-oxoacid transhydrogenase