Hydroperoxide dehydratase

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In enzymology, a hydroperoxide dehydratase (EC 4.2.1.92) is an enzyme that catalyzes the chemical reaction

(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate $\rightleftharpoons$ (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H₂O

Hence, this enzyme has one substrate, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and two products, (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]. Other names in common use include hydroperoxide isomerase, linoleate hydroperoxide isomerase, linoleic acid hydroperoxide isomerase, HPI, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and 12,13-hydro-lyase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U5U.

[edit] References

IUBMB entry for 4.2.1.92
BRENDA references for 4.2.1.92 (Recommended.)
PubMed references for 4.2.1.92
PubMed Central references for 4.2.1.92
Google Scholar references for 4.2.1.92
Esselman WJ, Clagett CO (1974). "Products of linoleic hydroperoxide-decomposing enzyme of alfalfa seed". J. Lipid. Res. 15: 173–8. PMID 4208994.
Hamberg M (1987). "Mechanism of corn hydroperoxide isomerase - detection of 12,13(S)-oxido-9(Z),11-octadecadienoic acid". Biochim. Biophys. Acta 920: 76–84.
Hamberg M (1988). "Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase". Biochem. Biophys. Res. Commun. 156: 543–50. PMID 3178850.