Hydrogen dehydrogenase (NADP+)

From Wikipedia, the free encyclopedia

In enzymology, a hydrogen dehydrogenase (NADP+) (EC 1.12.1.3) is an enzyme that catalyzes the chemical reaction

H₂ + NADP⁺ H⁺ + NADPH

Thus, the two substrates of this enzyme are H₂ and NADP⁺, whereas its two products are H⁺ and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NADP+ oxidoreductase. Other names in common use include NADP+-linked hydrogenase, NADP+-reducing hydrogenase, hydrogen dehydrogenase (NADP+), and simply hydrogenase (which is ambiguous).

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2AUV.

[edit] References

• IUBMB entry for 1.12.1.3
• BRENDA references for 1.12.1.3 (Recommended.)
• PubMed references for 1.12.1.3
• PubMed Central references for 1.12.1.3
• Google Scholar references for 1.12.1.3
• de Luca G, de Philip P, Rousset M, Belaich JP, Dermoun Z (1998). "The NADP-reducing hydrogenase of Desulfovibrio fructosovorans: evidence for a native complex with hydrogen-dependent methyl-viologen-reducing activity". Biochem. Biophys. Res. Commun. 248: 591–6. doi:10.1006/bbrc.1998.9022. PMID 9703971. 

[edit] External links

The CAS registry number for this enzyme class is 9027-05-8.

• IUBMB entry for 1.12.1.3

• KEGG entry for 1.12.1.3

• BRENDA entry for 1.12.1.3

• NiceZyme view of 1.12.1.3

• EC2PDB: PDB structures for 1.12.1.3

• PRIAM entry for 1.12.1.3

• PUMA2 entry for 1.12.1.3

• IntEnz: Integrated Enzyme entry for 1.12.1.3

• MetaCyc entry for 1.12.1.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050583: hydrogen dehydrogenase (NADP+)

• AMIGO entry for GO code 0050583: hydrogen dehydrogenase (NADP+)