Hydrogen dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a hydrogen dehydrogenase (EC 1.12.1.2) is an enzyme that catalyzes the chemical reaction

H₂ + NAD⁺ H⁺ + NADH

Thus, the two substrates of this enzyme are H₂ and NAD⁺, whereas its two products are H⁺ and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NAD+ oxidoreductase. Other names in common use include H2:NAD+ oxidoreductase, NAD+-linked hydrogenase, bidirectional hydrogenase, and hydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism and methane metabolism. It has 6 cofactors: FAD, Iron, FMN, Flavin, Nickel, and Iron-sulfur.

[edit] References

• IUBMB entry for 1.12.1.2
• BRENDA references for 1.12.1.2 (Recommended.)
• PubMed references for 1.12.1.2
• PubMed Central references for 1.12.1.2
• Google Scholar references for 1.12.1.2
• BONE DH, BERNSTEIN S, VISHNIAC W (1963). "Purification and some properties of different forms of hydrogen dehydrogenase". Biochim. Biophys. Acta. 67: 581–8. doi:10.1016/0006-3002(63)91868-7. PMID 13968752. 
• Schneider K, Schlegel HG (1976). "Purification and properties of soluble hydrogenase from Alcaligenes eutrophus H 16". Biochim. Biophys. Acta. 452: 66–80. PMID 186126. 

[edit] External links

The CAS registry number for this enzyme class is 9027-05-8.

• IUBMB entry for 1.12.1.2

• KEGG entry for 1.12.1.2

• BRENDA entry for 1.12.1.2

• NiceZyme view of 1.12.1.2

• EC2PDB: PDB structures for 1.12.1.2

• PRIAM entry for 1.12.1.2

• PUMA2 entry for 1.12.1.2

• IntEnz: Integrated Enzyme entry for 1.12.1.2

• MetaCyc entry for 1.12.1.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047985: hydrogen dehydrogenase

• AMIGO entry for GO code 0047985: hydrogen dehydrogenase