HUWE1

From Wikipedia, the free encyclopedia

HECT, UBA and WWE domain containing 1

Identifiers

HUWE1; ARF-BP1; HECTH9; HSPC272; Ib772; KIAA0312; LASU1; MULE; UREB1

External IDs

MGI: 1926884 HomoloGene: 45994

Gene ontology
Molecular Function:	• DNA binding • ubiquitin-protein ligase activity • protein binding • ligase activity
Cellular Component:	• intracellular • nucleus • cytoplasm
Biological Process:	• protein polyubiquitination • ubiquitin cycle • histone ubiquitination • mRNA transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_031407 (mRNA)
NP_113584 (protein)

NM_021523 (mRNA)
NP_067498 (protein)

Location

Chr X: 53.58 - 53.73 Mb

Chr X: 147.14 - 147.28 Mb

Pubmed search

[1]

[2]

HECT, UBA and WWE domain containing 1, also known as HUWE1, is a human gene.^[1]

[edit] References

^ Entrez Gene: HUWE1 HECT, UBA and WWE domain containing 1.

[edit] Further reading

Jackson PK, Eldridge AG, Freed E, et al. (2000). "The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases.". Trends Cell Biol. 10 (10): 429–39. PMID 10998601.
Gu J, Dubner R, Fornace AJ, Iadarola MJ (1995). "UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation.". Oncogene 11 (10): 2175–8. PMID 7478539.
Gu J, Ren K, Dubner R, Iadarola MJ (1994). "Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene.". Brain Res. Mol. Brain Res. 24 (1-4): 77–88. PMID 7968380.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. PMID 9205841.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. PMID 10997877.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Yoon SY, Lee Y, Kim JH, et al. (2005). "Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein.". Biochem. Biophys. Res. Commun. 326 (1): 7–17. doi:10.1016/j.bbrc.2004.11.004. PMID 15567145.
Liu Z, Oughtred R, Wing SS (2005). "Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones.". Mol. Cell. Biol. 25 (7): 2819–31. doi:10.1128/MCB.25.7.2819-2831.2005. PMID 15767685.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Chen D, Kon N, Li M, et al. (2005). "ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.". Cell 121 (7): 1071–83. doi:10.1016/j.cell.2005.03.037. PMID 15989956.
Zhong Q, Gao W, Du F, Wang X (2005). "Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.". Cell 121 (7): 1085–95. doi:10.1016/j.cell.2005.06.009. PMID 15989957.
Warr MR, Acoca S, Liu Z, et al. (2005). "BH3-ligand regulates access of MCL-1 to its E3 ligase.". FEBS Lett. 579 (25): 5603–8. doi:10.1016/j.febslet.2005.09.028. PMID 16213503.
Adhikary S, Marinoni F, Hock A, et al. (2005). "The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation.". Cell 123 (3): 409–21. doi:10.1016/j.cell.2005.08.016. PMID 16269333.