Humanized mouse

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The “humanized mouse” is a mouse carrying functioning human genes, cells, tissues, and/or organs that are initially transplanted and grown in it. It has been often used as in-vivo human models in the area of biological and medical research for human therapeutics. Immunodeficient mouse, such as, nude mouse, severe combined immunodeficiency (SCID) mouse, and NOG mouse, has been used as a recipient for the humanized mouse, since it can relatively easily accept heterologous cells due to lack of immunity to reject them. Traditionally, nude mouse and SCID mouse are popularly used for the purpose but recently NOG mouse[1], which is the most severely immunodeficient, is found to be the best recipient animal among all. [2][3]

Contents

[edit] Concept

[edit] History

[edit] Category

[edit] Mouse and material

[edit] Applications

There are many promising biomedical research applications for human therapeutics including:

[edit] Promising future

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[edit] References

  1. ^ M. Ito and et.al. (2002). "NOD/SCID/γnull mouse: an excellent recipient mouse model for engraftment of human cells". Blood 100: 3175–3182. doi:10.1182/blood-2001-12-0207. 
  2. ^ T. Nomura, N. Tamaoki, A. Takakura and et.al. (2008), T. Nomura, T. Watanabe, and S. Habu, ed., Basic Concept of Development and Practical Application of Animal Models for Human Diseases, In: Humanized Mice; Current Topics in Microbiology and Immunology, Springer-Verlag, Berlin and Heidelberg, pp. 1-22 
  3. ^ M. Ito, K. Kobayashi12 and T. Nakahata (2008), T. Nomura, T. Watanabe, and S. Habu, ed., NOD/Shi-scid IL2rγnull (NOG) Mice More Appropriate for Humanized Mouse Models; Current Topics in Microbiology and Immunology, Springer-Verlag, Berlin and Heidelberg, pp. 53-76