HTATSF1

From Wikipedia, the free encyclopedia

HIV-1 Tat specific factor 1

PDB rendering based on 2dit.

Available structures: 2dit

Identifiers

Symbol(s)

HTATSF1; TAT-SF1; dJ196E23.2

External IDs

OMIM: 300346 MGI: 1919709 HomoloGene: 40950

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA polymerase II transcription factor activity • transcription elongation regulator activity • RNA binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription from RNA polymerase II promoter • viral genome replication

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014500 (mRNA)
NP_055315 (protein)

NM_028242 (mRNA)
NP_082518 (protein)

Location

Chr X: 135.41 - 135.42 Mb

Chr X: 53.4 - 53.41 Mb

Pubmed search

[1]

[2]

HIV-1 Tat specific factor 1, also known as HTATSF1, is a human gene.^[1]

Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.". Science 274 (5287): 605-10. PMID 8849451.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Zhou Q, Chen D, Pierstorff E, Luo K (1998). "Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages.". EMBO J. 17 (13): 3681-91. doi:10.1093/emboj/17.13.3681. PMID 9649438.
Yan D, Perriman R, Igel H, et al. (1998). "CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif.". Mol. Cell. Biol. 18 (9): 5000-9. PMID 9710584.
Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.". Genes Dev. 12 (19): 2992-6. PMID 9765201.
Parada CA, Roeder RG (1999). "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.". EMBO J. 18 (13): 3688-701. doi:10.1093/emboj/18.13.3688. PMID 10393184.
Kim JB, Yamaguchi Y, Wada T, et al. (1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins.". Mol. Cell. Biol. 19 (9): 5960-8. PMID 10454543.
Fong YW, Zhou Q (2000). "Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter.". Mol. Cell. Biol. 20 (16): 5897-907. PMID 10913173.
Suñé C, Goldstrohm AC, Peng J, et al. (2000). "An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.". Virology 274 (2): 356-66. doi:10.1006/viro.2000.0480. PMID 10964778.
Simmons A, Aluvihare V, McMichael A (2001). "Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators.". Immunity 14 (6): 763-77. PMID 11420046.
Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation.". Nature 414 (6866): 929-33. doi:10.1038/414929a. PMID 11780068.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhou BY, He JJ (2004). "Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein.". Neurosci. Lett. 359 (3): 155-8. doi:10.1016/j.neulet.2004.02.012. PMID 15050687.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Smith MJ, Kulkarni S, Pawson T (2004). "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions.". Mol. Cell. Biol. 24 (21): 9274-85. doi:10.1128/MCB.24.21.9274-9285.2004. PMID 15485897.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zhou M, Deng L, Lacoste V, et al. (2004). "Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.". J. Virol. 78 (24): 13522-33. doi:10.1128/JVI.78.24.13522-13533.2004. PMID 15564463.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
Missé D, Gajardo J, Oblet C, et al. (2005). "Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression.". AIDS 19 (9): 897-905. PMID 15905670.