HSPA9

From Wikipedia, the free encyclopedia

Heat shock 70kDa protein 9 (mortalin)

Identifiers

HSPA9; CSA; GRP75; HSPA9B; MGC4500; MOT; MOT2; MTHSP75; PBP74; mot-2

External IDs

OMIM: 600548 MGI: 96245 HomoloGene: 39452

Gene ontology
Molecular Function:	• nucleotide binding • ATP binding • unfolded protein binding
Cellular Component:	• cytoplasm • mitochondrion • cell surface
Biological Process:	• protein folding • protein export from nucleus • anti-apoptosis • response to unfolded protein

Orthologs

Human

Mouse

Entrez

3313

15526

Refseq

NM_004134 (mRNA)
NP_004125 (protein)

NM_010481 (mRNA)
NP_034611 (protein)

Pubmed search

[1]

[2]

Heat shock 70kDa protein 9 (mortalin), also known as HSPA9, is a human gene.^[1]

The product encoded by this gene belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This gene encodes a heat-shock cognate protein. This protein plays a role in the control of cell proliferation. It may also act as a chaperone.^[1]

[edit] References

^ ^a ^b Entrez Gene: HSPA9 heat shock 70kDa protein 9 (mortalin).

[edit] Further reading

Kaul SC, Taira K, Pereira-Smith OM, Wadhwa R (2003). "Mortalin: present and prospective.". Exp. Gerontol. 37 (10-11): 1157–64. PMID 12470827.
Yaguchi T, Aida S, Kaul SC, Wadhwa R (2007). "Involvement of mortalin in cellular senescence from the perspective of its mitochondrial import, chaperone, and oxidative stress management functions.". Ann. N. Y. Acad. Sci. 1100: 306–11. doi:10.1196/annals.1395.032. PMID 17460192.
Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison.". Electrophoresis 13 (12): 992–1001. PMID 1286669.
Domanico SZ, DeNagel DC, Dahlseid JN, et al. (1993). "Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family.". Mol. Cell. Biol. 13 (6): 3598–610. PMID 7684501.
Kaul SC, Wadhwa R, Matsuda Y, et al. (1995). "Mouse and human chromosomal assignments of mortalin, a novel member of the murine hsp70 family of proteins.". FEBS Lett. 361 (2-3): 269–72. PMID 7698336.
Bhattacharyya T, Karnezis AN, Murphy SP, et al. (1995). "Cloning and subcellular localization of human mitochondrial hsp70.". J. Biol. Chem. 270 (4): 1705–10. PMID 7829505.
Furlini G, Vignoli M, Re MC, et al. (1994). "Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein.". J. Gen. Virol. 75 ( Pt 1): 193–9. PMID 7906708.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. PMID 8076819.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Hughes GJ, Frutiger S, Paquet N, et al. (1994). "Human liver protein map: update 1993.". Electrophoresis 14 (11): 1216–22. PMID 8313870.
Ji H, Reid GE, Moritz RL, et al. (1997). "A two-dimensional gel database of human colon carcinoma proteins.". Electrophoresis 18 (3-4): 605–13. doi:10.1002/elps.1150180344. PMID 9150948.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Mizukoshi E, Suzuki M, Loupatov A, et al. (1999). "Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin.". Biochem. J. 343 Pt 2: 461–6. PMID 10510314.
O'Keeffe B, Fong Y, Chen D, et al. (2000). "Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription.". J. Biol. Chem. 275 (1): 279–87. PMID 10617616.
Kaula SC, Reddelb RR, Sugiharac T, et al. (2000). "Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2.". FEBS Lett. 474 (2-3): 159–64. PMID 10838077.
Agostini I, Popov S, Li J, et al. (2000). "Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex.". Exp. Cell Res. 259 (2): 398–403. doi:10.1006/excr.2000.4992. PMID 10964507.
Xie H, Hu Z, Chyna B, et al. (2001). "Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31.". Leukemia 14 (12): 2128–34. PMID 11187902.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Carette J, Lehnert S, Chow TY (2002). "Implication of PBP74/mortalin/GRP75 in the radio-adaptive response.". Int. J. Radiat. Biol. 78 (3): 183–90. doi:10.1080/09553000110097208. PMID 11869473.
Wadhwa R, Yaguchi T, Hasan MK, et al. (2002). "Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein.". Exp. Cell Res. 274 (2): 246–53. doi:10.1006/excr.2002.5468. PMID 11900485.