HSPA1L

From Wikipedia, the free encyclopedia


Heat shock 70kDa protein 1-like
PDB rendering based on 1hjo.
Available structures: 1hjo, 1s3x, 1xqs
Identifiers
Symbol(s) HSPA1L; HSP70-HOM; hum70t
External IDs OMIM: 140559 MGI: 96231 HomoloGene: 74557
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3305 15482
Ensembl ENSG00000204390 ENSMUSG00000007033
Uniprot P34931 Q91ZU4
Refseq NM_005527 (mRNA)
NP_005518 (protein)		 NM_013558 (mRNA)
NP_038586 (protein)
Location Chr 6: 31.89 - 31.89 Mb Chr 17: 34.58 - 34.59 Mb
Pubmed search [1] [2]

Heat shock 70kDa protein 1-like, also known as HSPA1L, is a human gene.[1]

This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein.[1]

[edit] References

  1. ^ a b Entrez Gene: HSPA1L heat shock 70kDa protein 1-like.

[edit] Further reading

  • Ishihara M, Ohno S (1997). "Genetic influences on sarcoidosis.". Eye (London, England) 11 ( Pt 2): 155-61. PMID 9349405. 
  • Milner CM, Campbell RD (1992). "Polymorphic analysis of the three MHC-linked HSP70 genes.". Immunogenetics 36 (6): 357-62. PMID 1356099. 
  • Milner CM, Campbell RD (1990). "Structure and expression of the three MHC-linked HSP70 genes.". Immunogenetics 32 (4): 242-51. PMID 1700760. 
  • Sargent CA, Dunham I, Trowsdale J, Campbell RD (1989). "Human major histocompatibility complex contains genes for the major heat shock protein HSP70.". Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1968-72. PMID 2538825. 
  • Goate AM, Cooper DN, Hall C, et al. (1987). "Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis.". Hum. Genet. 75 (2): 123-8. PMID 2880793. 
  • Harrison GS, Drabkin HA, Kao FT, et al. (1987). "Chromosomal location of human genes encoding major heat-shock protein HSP70.". Somat. Cell Mol. Genet. 13 (2): 119-30. PMID 3470951. 
  • Voellmy R, Ahmed A, Schiller P, et al. (1985). "Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment.". Proc. Natl. Acad. Sci. U.S.A. 82 (15): 4949-53. PMID 3927293. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Ito Y, Ando A, Ando H, et al. (1998). "Genomic structure of the spermatid-specific hsp70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man.". J. Biochem. 124 (2): 347-53. PMID 9685725. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Fourie AM, Peterson PA, Yang Y (2002). "Characterization and regulation of the major histocompatibility complex-encoded proteins Hsp70-Hom and Hsp70-1/2.". Cell Stress Chaperones 6 (3): 282-95. PMID 11599570. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Schröder O, Schulte KM, Ostermann P, et al. (2003). "Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury.". Crit. Care Med. 31 (1): 73-9. doi:10.1097/01.CCM.0000037972.16578.2B. PMID 12544996. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404. 
  • Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621-36. doi:10.1101/gr.1736803. PMID 14656967. 
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
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