HSD17B8

From Wikipedia, the free encyclopedia

Hydroxysteroid (17-beta) dehydrogenase 8

PDB rendering based on 2pd6.

Available structures: 2pd6

Identifiers

Symbol(s)

HSD17B8; RING2; D6S2245E; FABG; FABGL; H2-KE6; HKE6; KE6; dJ1033B10.9

External IDs

OMIM: 601417 MGI: 95911 HomoloGene: 56588

Gene ontology
Molecular Function:	• estradiol 17-beta-dehydrogenase activity • oxidoreductase activity • testosterone 17-beta-dehydrogenase activity
Cellular Component:	• cellular_component • membrane fraction • mitochondrion • mitochondrial envelope • plasma membrane
Biological Process:	• estrogen biosynthetic process • metabolic process • androgen metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014234 (mRNA)
NP_055049 (protein)

NM_013543 (mRNA)
NP_038571 (protein)

Location

Chr c6_QBL: 33.24 - 33.25 Mb

Chr 17: 33.64 - 33.64 Mb

Pubmed search

[1]

[2]

Hydroxysteroid (17-beta) dehydrogenase 8, also known as HSD17B8, is a human gene.^[1]

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8.

[edit] Further reading

Ando A, Kikuti YY, Shigenari A, et al. (1996). "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region.". Genomics 35 (3): 600-2. doi:10.1006/geno.1996.0405. PMID 8812499.
Kikuti YY, Tamiya G, Ando A, et al. (1997). "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes.". Genomics 42 (3): 422-35. doi:10.1006/geno.1997.4745. PMID 9205114.
Fomitcheva J, Baker ME, Anderson E, et al. (1998). "Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues.". J. Biol. Chem. 273 (35): 22664-71. PMID 9712896.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Aziz N, Anderson E, Lee GY, Woo DD (2001). "Arrested testis development in the cpk mouse may be the result of abnormal steroid metabolism.". Mol. Cell. Endocrinol. 171 (1-2): 83-8. PMID 11165015.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome.". Nucleic Acids Res. 30 (14): 3163-70. PMID 12136098.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Song D, Liu G, Luu-The V, et al. (2006). "Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study.". J. Steroid Biochem. Mol. Biol. 101 (2-3): 136-44. doi:10.1016/j.jsbmb.2006.06.015. PMID 16930994.
Villar J, Celay J, Alonso MM, et al. (2007). "Transcriptional regulation of the human type 8 17beta-hydroxysteroid dehydrogenase gene by C/EBPbeta.". J. Steroid Biochem. Mol. Biol. 105 (1-5): 131-9. doi:10.1016/j.jsbmb.2006.12.106. PMID 17583490.