HSD17B2

From Wikipedia, the free encyclopedia

Hydroxysteroid (17-beta) dehydrogenase 2

Identifiers

HSD17B2; EDH17B2; HSD17

External IDs

OMIM: 109685 MGI: 1096386 HomoloGene: 31076

Gene ontology
Molecular Function:	• estradiol 17-beta-dehydrogenase activity • oxidoreductase activity
Cellular Component:	• endoplasmic reticulum membrane • membrane • integral to membrane
Biological Process:	• estrogen biosynthetic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002153 (mRNA)
NP_002144 (protein)

NM_008290 (mRNA)
NP_032316 (protein)

Location

Chr 16: 80.63 - 80.69 Mb

Chr 8: 120.59 - 120.65 Mb

Pubmed search

[1]

[2]

Hydroxysteroid (17-beta) dehydrogenase 2, also known as HSD17B2, is a human gene.^[1]

[edit] References

^ Entrez Gene: HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2.

[edit] Further reading

Labrie Y, Durocher F, Lachance Y, et al. (1995). "The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species.". DNA Cell Biol. 14 (10): 849-61. PMID 7546291.
Andersson S, Geissler WM, Patel S, Wu L (1995). "The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases.". J. Steroid Biochem. Mol. Biol. 53 (1-6): 37-9. PMID 7626483.
Durocher F, Morissette J, Labrie Y, et al. (1995). "Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2.". Genomics 25 (3): 724-6. PMID 7759109.
Carsol JL, Martin PM, de Launoit Y (1995). "Characterization of 17 beta-hydroxysteroid dehydrogenase activity and mRNA abundance in human meningioma tumors.". Neuroendocrinology 60 (4): 445-51. PMID 7824086.
Wu L, Einstein M, Geissler WM, et al. (1993). "Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity.". J. Biol. Chem. 268 (17): 12964-9. PMID 8099587.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Zhang Y, Word RA, Fesmire S, et al. (1996). "Human ovarian expression of 17 beta-hydroxysteroid dehydrogenase types 1, 2, and 3.". J. Clin. Endocrinol. Metab. 81 (10): 3594-8. PMID 8855807.
Moghrabi N, Head JR, Andersson S (1997). "Cell type-specific expression of 17 beta-hydroxysteroid dehydrogenase type 2 in human placenta and fetal liver.". J. Clin. Endocrinol. Metab. 82 (11): 3872-8. PMID 9360554.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Corbould AM, Judd SJ, Rodgers RJ (1998). "Expression of types 1, 2, and 3 17 beta-hydroxysteroid dehydrogenase in subcutaneous abdominal and intra-abdominal adipose tissue of women.". J. Clin. Endocrinol. Metab. 83 (1): 187-94. PMID 9435439.
Dong Y, Qiu QQ, Debear J, et al. (1999). "17Beta-hydroxysteroid dehydrogenases in human bone cells.". J. Bone Miner. Res. 13 (10): 1539-46. PMID 9783542.
Kitawaki J, Koshiba H, Ishihara H, et al. (2000). "Progesterone induction of 17beta-hydroxysteroid dehydrogenase type 2 during the secretory phase occurs in the endometrium of estrogen-dependent benign diseases but not in normal endometrium.". J. Clin. Endocrinol. Metab. 85 (9): 3292-6. PMID 10999824.
Sano T, Hirasawa G, Takeyama J, et al. (2001). "17 beta-Hydroxysteroid dehydrogenase type 2 expression and enzyme activity in the human gastrointestinal tract.". Clin. Sci. 101 (5): 485-91. PMID 11672453.
Lu ML, Huang YW, Lin SX (2002). "Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2.". J. Biol. Chem. 277 (25): 22123-30. doi:10.1074/jbc.M111726200. PMID 11940569.
Provost PR, Blomquist CH, Drolet R, et al. (2002). "Androgen inactivation in human lung fibroblasts: variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 and 5 alpha-reductase activity compatible with androgen inactivation.". J. Clin. Endocrinol. Metab. 87 (8): 3883-92. PMID 12161528.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Oliveira IO, Lhullier C, Brum IS, Spritzer PM (2004). "Gene expression of type 2 17 beta hydroxysteroid dehydrogenase in scalp hairs of hirsute women.". Steroids 68 (7-8): 641-9. PMID 12957669.
Oduwole OO, Mäkinen JM, Isomaa VV, et al. (2004). "Sex steroid metabolism in human gastric mucosa: 17 beta-hydroxysteroid dehydrogenase type 2 in normal, inflamed and neoplastic gastric tissues.". Anticancer Res. 23 (5A): 3889-97. PMID 14666693.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Matsuzaki S, Canis M, Pouly JL, et al. (2006). "Analysis of aromatase and 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression in deep endometriosis and eutopic endometrium using laser capture microdissection.". Fertil. Steril. 85 (2): 308-13. doi:10.1016/j.fertnstert.2005.08.017. PMID 16595205.