HSD17B12

From Wikipedia, the free encyclopedia

Hydroxysteroid (17-beta) dehydrogenase 12

Identifiers

External IDs

OMIM: 609574 MGI: 1926967 HomoloGene: 68590

Gene ontology
Molecular Function:	• estradiol 17-beta-dehydrogenase activity • oxidoreductase activity
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• steroid biosynthetic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016142 (mRNA)
NP_057226 (protein)

NM_019657 (mRNA)
NP_062631 (protein)

Location

Chr 11: 43.66 - 43.83 Mb

Chr 2: 93.83 - 93.96 Mb

Pubmed search

[1]

[2]

Hydroxysteroid (17-beta) dehydrogenase 12, also known as HSD17B12, is a human gene.^[1]

The enzyme 17-beta hydroxysteroid dehydrogenase-12 (HSD17B12) uses NADPH to reduce 3-ketoacyl-CoA to 3-hydroxyacyl-CoA during the second step of fatty acid elongation.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Moon YA, Horton JD (2003). "Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade.". J. Biol. Chem. 278 (9): 7335-43. doi:10.1074/jbc.M211684200. PMID 12482854.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Gnatenko DV, Cupit LD, Huang EC, et al. (2005). "Platelets express steroidogenic 17beta-hydroxysteroid dehydrogenases. Distinct profiles predict the essential thrombocythemic phenotype.". Thromb. Haemost. 94 (2): 412-21. doi:10.1267/THRO05020412. PMID 16113833.
Luu-The V, Tremblay P, Labrie F (2006). "Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women.". Mol. Endocrinol. 20 (2): 437-43. doi:10.1210/me.2005-0058. PMID 16166196.
Sakurai N, Miki Y, Suzuki T, et al. (2006). "Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12.". J. Steroid Biochem. Mol. Biol. 99 (4-5): 174-81. doi:10.1016/j.jsbmb.2006.01.010. PMID 16621523.