HS3ST2

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Heparan sulfate (glucosamine) 3-O-sulfotransferase 2
Identifiers
Symbol(s) HS3ST2; 30ST2; 3OST2
External IDs OMIM: 604056 MGI: 1333802 HomoloGene: 21220
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9956 195646
Ensembl ENSG00000122254 ENSMUSG00000046321
Uniprot Q9Y278 Q673U1
Refseq NM_006043 (mRNA)
NP_006034 (protein)		 XM_112440 (mRNA)
XP_112440 (protein)
Location Chr 16: 22.73 - 22.84 Mb Chr 7: 121.18 - 121.29 Mb
Pubmed search [1] [2]

Heparan sulfate (glucosamine) 3-O-sulfotransferase 2, also known as HS3ST2, is a human gene.[1]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system.[1]

[edit] References

  1. ^ a b Entrez Gene: HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2.

[edit] Further reading

  • Lawrence R, Yabe T, Hajmohammadi S, et al. (2007). "The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues.". Matrix Biol. 26 (6): 442-55. doi:10.1016/j.matbio.2007.03.002. PMID 17482450. 
  • O'Donnell CD, Tiwari V, Oh MJ, Shukla D (2006). "A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread.". Virology 346 (2): 452-9. doi:10.1016/j.virol.2005.11.003. PMID 16336986. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Miyamoto K, Asada K, Fukutomi T, et al. (2003). "Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers.". Oncogene 22 (2): 274-80. doi:10.1038/sj.onc.1206146. PMID 12527896. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Liu J, Shworak NW, Sinaÿ P, et al. (1999). "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities.". J. Biol. Chem. 274 (8): 5185-92. PMID 9988768. 
  • Shworak NW, Liu J, Petros LM, et al. (1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci.". J. Biol. Chem. 274 (8): 5170-84. PMID 9988767. 
  • Razi N, Lindahl U (1995). "Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides.". J. Biol. Chem. 270 (19): 11267-75. PMID 7744762. 
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