HS2ST1

From Wikipedia, the free encyclopedia

Heparan sulfate 2-O-sulfotransferase 1

Identifiers

HS2ST1; FLJ11317; KIAA0448; MGC131986; dJ604K5.2

External IDs

OMIM: 604844 MGI: 1346049 HomoloGene: 8025

Gene ontology
Molecular Function:	• heparan sulfate 2-O-sulfotransferase activity • transferase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process • heparin metabolic process

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_012262 (mRNA)
NP_036394 (protein)

NM_011828 (mRNA)
NP_035958 (protein)

Location

n/a

Chr 3: 144.37 - 144.51 Mb

Pubmed search

[1]

[2]

Heparan sulfate 2-O-sulfotransferase 1, also known as HS2ST1, is a human gene.^[1]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.^[1]

[edit] References

^ ^a ^b Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1.

[edit] Further reading

Muramatsu T (2000). "Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting.". J. Biochem. 127 (2): 171–6. PMID 10731680.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.". DNA Res. 4 (5): 345–9. PMID 9455484.
Rong J, Habuchi H, Kimata K, et al. (2000). "Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation.". Biochem. J. 346 Pt 2: 463–8. PMID 10677367.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Aquino RS, Landeira-Fernandez AM, Valente AP, et al. (2005). "Occurrence of sulfated galactans in marine angiosperms: evolutionary implications.". Glycobiology 15 (1): 11–20. doi:10.1093/glycob/cwh138. PMID 15317737.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Xu D, Song D, Pedersen LC, Liu J (2007). "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.". J. Biol. Chem. 282 (11): 8356–67. doi:10.1074/jbc.M608062200. PMID 17227754.