HPR (gene)

From Wikipedia, the free encyclopedia

Haptoglobin-related protein

Identifiers

HPR; HP; A-259H10.2

External IDs

OMIM: 140210 MGI: 96211 HomoloGene: 8273

Gene ontology
Molecular Function:	• serine-type endopeptidase activity • hemoglobin binding
Cellular Component:	• extracellular region
Biological Process:	• proteolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020995 (mRNA)
NP_066275 (protein)

NM_017370 (mRNA)
NP_059066 (protein)

Location

Chr 16: 70.67 - 70.67 Mb

Chr 8: 112.46 - 112.47 Mb

Pubmed search

[1]

[2]

Haptoglobin-related protein, also known as HPR, is a human gene.^[1]

[edit] See also

Haptoglobin

[edit] References

^ Entrez Gene: HPR haptoglobin-related protein.

[edit] Further reading

Erickson LM, Kim HS, Maeda N (1993). "Junctions between genes in the haptoglobin gene cluster of primates.". Genomics 14 (4): 948–58. PMID 1478675.
Maeda N, McEvoy SM, Harris HF, et al. (1986). "Polymorphisms in the human haptoglobin gene cluster: chromosomes with multiple haptoglobin-related (Hpr) genes.". Proc. Natl. Acad. Sci. U.S.A. 83 (19): 7395–9. PMID 2876426.
Maeda N (1985). "Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element.". J. Biol. Chem. 260 (11): 6698–709. PMID 2987228.
Bensi G, Raugei G, Klefenz H, Cortese R (1985). "Structure and expression of the human haptoglobin locus.". EMBO J. 4 (1): 119–26. PMID 4018023.
Smith AB, Esko JD, Hajduk SL (1995). "Killing of trypanosomes by the human haptoglobin-related protein.". Science 268 (5208): 284–6. PMID 7716520.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Tabak S, Lev A, Valansi C, et al. (1997). "Transcriptionally active haptoglobin-related (Hpr) gene in hepatoma G2 and leukemia molt-4 cells.". DNA Cell Biol. 15 (11): 1001–7. PMID 8945641.
Muranjan M, Nussenzweig V, Tomlinson S (1998). "Characterization of the human serum trypanosome toxin, haptoglobin-related protein.". J. Biol. Chem. 273 (7): 3884–7. PMID 9461571.
Raper J, Fung R, Ghiso J, et al. (1999). "Characterization of a novel trypanosome lytic factor from human serum.". Infect. Immun. 67 (4): 1910–6. PMID 10085035.
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMID 11752456.
Hatada S, Seed JR, Barker C, et al. (2002). "No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein.". Mol. Biochem. Parasitol. 119 (2): 291–4. PMID 11814582.
Nielsen MJ, Petersen SV, Jacobsen C, et al. (2006). "Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein.". Blood 108 (8): 2846–9. doi:10.1182/blood-2006-05-022327. PMID 16778136.
Vanhollebeke B, Nielsen MJ, Watanabe Y, et al. (2007). "Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 4118–23. doi:10.1073/pnas.0609902104. PMID 17360487.
Widener J, Nielsen MJ, Shiflett A, et al. (2007). "Hemoglobin is a co-factor of human trypanosome lytic factor.". PLoS Pathog. 3 (9): 1250–61. doi:10.1371/journal.ppat.0030129. PMID 17845074.