HPN (gene)

From Wikipedia, the free encyclopedia

Hepsin (transmembrane protease, serine 1)

PDB rendering based on 1o5e.

Available structures: 1o5e, 1o5f, 1p57, 1z8g

Identifiers

Symbol(s)

HPN; TMPRSS1

External IDs

OMIM: 142440 MGI: 1196620 HomoloGene: 20498

Gene ontology
Molecular Function:	• serine-type endopeptidase activity • scavenger receptor activity
Cellular Component:	• plasma membrane • integral to plasma membrane
Biological Process:	• proteolysis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002151 (mRNA)
NP_002142 (protein)

NM_008281 (mRNA)
NP_032307 (protein)

Location

Chr 19: 40.22 - 40.25 Mb

Chr 7: 30.81 - 30.82 Mb

Pubmed search

[1]

[2]

Hepsin (transmembrane protease, serine 1), also known as HPN, is a human gene.^[1]

Hepsin is a cell surface serine protease.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: HPN hepsin (transmembrane protease, serine 1).

[edit] Further reading

Wu Q (2001). "Gene targeting in hemostasis. Hepsin.". Front. Biosci. 6: D192–200. PMID 11171558.
Tsuji A, Torres-Rosado A, Arai T, et al. (1991). "Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization.". J. Biol. Chem. 266 (25): 16948–53. PMID 1885621.
Leytus SP, Loeb KR, Hagen FS, et al. (1988). "A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells.". Biochemistry 27 (3): 1067–74. PMID 2835076.
Kazama Y, Hamamoto T, Foster DC, Kisiel W (1995). "Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation.". J. Biol. Chem. 270 (1): 66–72. PMID 7814421.
Torres-Rosado A, O'Shea KS, Tsuji A, et al. (1993). "Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth.". Proc. Natl. Acad. Sci. U.S.A. 90 (15): 7181–5. PMID 8346233.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chen Z, Fan Z, McNeal JE, et al. (2003). "Hepsin and maspin are inversely expressed in laser capture microdissectioned prostate cancer.". J. Urol. 169 (4): 1316–9. doi:10.1097/01.ju.0000050648.40164.0d. PMID 12629351.
Somoza JR, Ho JD, Luong C, et al. (2004). "The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain.". Structure 11 (9): 1123–31. PMID 12962630.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kirchhofer D, Peek M, Lipari MT, et al. (2005). "Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.". FEBS Lett. 579 (9): 1945–50. doi:10.1016/j.febslet.2005.01.085. PMID 15792801.
Pal P, Xi H, Kaushal R, et al. (2007). "Variants in the HEPSIN gene are associated with prostate cancer in men of European origin.". Hum. Genet. 120 (2): 187–92. doi:10.1007/s00439-006-0204-3. PMID 16783571.
Moran P, Li W, Fan B, et al. (2006). "Pro-urokinase-type plasminogen activator is a substrate for hepsin.". J. Biol. Chem. 281 (41): 30439–46. doi:10.1074/jbc.M605440200. PMID 16908524.
Betsunoh H, Mukai S, Akiyama Y, et al. (2007). "Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma.". Cancer Sci. 98 (4): 491–8. doi:10.1111/j.1349-7006.2007.00412.x. PMID 17309599.