HPGD

From Wikipedia, the free encyclopedia


Hydroxyprostaglandin dehydrogenase 15-(NAD)
PDB rendering based on 2gdz.
Available structures: 2gdz
Identifiers
Symbol(s) HPGD; 15-PGDH; PGDH; PGDH1
External IDs OMIM: 601688 MGI108085 HomoloGene68095
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 3248 15446
Ensembl ENSG00000164120 ENSMUSG00000031613
Uniprot P15428 Q8VCC1
Refseq NM_000860 (mRNA)
NP_000851 (protein)
NM_008278 (mRNA)
NP_032304 (protein)
Location Chr 4: 175.65 - 175.68 Mb Chr 8: 59.19 - 59.21 Mb
Pubmed search [1] [2]

Hydroxyprostaglandin dehydrogenase 15-(NAD), also known as HPGD, is a human gene.[1]


[edit] References

[edit] Further reading

  • Erwich JJ, Keirse MJ (1992). "Placental localization of 15-hydroxy-prostaglandin dehydrogenase in early and term human pregnancy.". Placenta 13 (3): 223-9. PMID 1635910. 
  • Ensor CM, Yang JY, Okita RT, Tai HH (1990). "Cloning and sequence analysis of the cDNA for human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.". J. Biol. Chem. 265 (25): 14888-91. PMID 1697582. 
  • Ensor CM, Tai HH (1991). "Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme.". Biochem. Biophys. Res. Commun. 176 (2): 840-5. PMID 2025296. 
  • Krook M, Marekov L, Jörnvall H (1990). "Purification and structural characterization of placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family.". Biochemistry 29 (3): 738-43. PMID 2337593. 
  • Pichaud F, Frendo JL, Delage-Mourroux R, et al. (1995). "Sequence of a novel mRNA coding for a C-terminal-truncated form of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.". Gene 162 (2): 319-22. PMID 7557451. 
  • Sangha RK, Walton JC, Ensor CM, et al. (1994). "Immunohistochemical localization, messenger ribonucleic acid abundance, and activity of 15-hydroxyprostaglandin dehydrogenase in placenta and fetal membranes during term and preterm labor.". J. Clin. Endocrinol. Metab. 78 (4): 982-9. PMID 8157731. 
  • Krook M, Ghosh D, Duax W, Jörnvall H (1993). "Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase).". FEBS Lett. 322 (2): 139-42. PMID 8482380. 
  • Pichaud F, Delage-Mourroux R, Pidoux E, et al. (1997). "Chromosomal localization of the type-I 15-PGDH gene to 4q34-q35.". Hum. Genet. 99 (2): 279-81. PMID 9048936. 
  • Delage-Mourroux R, Pichaud F, Frendo JL, et al. (1997). "Cloning and sequencing of a new 15-hydroxyprostaglandin dehydrogenase related mRNA.". Gene 188 (1): 143-8. PMID 9099873. 
  • Patel FA, Clifton VL, Chwalisz K, Challis JR (1999). "Steroid regulation of prostaglandin dehydrogenase activity and expression in human term placenta and chorio-decidua in relation to labor.". J. Clin. Endocrinol. Metab. 84 (1): 291-9. PMID 9920098. 
  • Zhou H, Tai HH (1999). "Threonine 188 is critical for interaction with NAD+ in human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase.". Biochem. Biophys. Res. Commun. 257 (2): 414-7. doi:10.1006/bbrc.1999.0356. PMID 10198228. 
  • Greenland KJ, Jantke I, Jenatschke S, et al. (2000). "The human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene promoter is controlled by Ets and activating protein-1 transcription factors and progesterone.". Endocrinology 141 (2): 581-97. PMID 10650939. 
  • Conner CE, Kelly RW, Hume R (2001). "Regulation of prostaglandin availability in human fetal lung by differential localisation of prostaglandin H synthase-1 and prostaglandin dehydrogenase.". Histochem. Cell Biol. 116 (4): 313-9. doi:10.1007/s004180100323. PMID 11702189. 
  • Giannoulias D, Patel FA, Holloway AC, et al. (2002). "Differential changes in 15-hydroxyprostaglandin dehydrogenase and prostaglandin H synthase (types I and II) in human pregnant myometrium.". J. Clin. Endocrinol. Metab. 87 (3): 1345-52. PMID 11889207. 
  • Cho H, Tai HH (2003). "Threonine 11 of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase may interact with NAD(+) during catalysis.". Prostaglandins Leukot. Essent. Fatty Acids 66 (5-6): 505-9. PMID 12144871. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tai HH, Ensor CM, Zhou H, Yan F (2003). "Structure and function of human NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase.". Adv. Exp. Med. Biol. 507: 245-50. PMID 12664592. 
  • McKeown KJ, Challis JR (2003). "Regulation of 15-hydroxy prostaglandin dehydrogenase by corticotrophin-releasing hormone through a calcium-dependent pathway in human chorion trophoblast cells.". J. Clin. Endocrinol. Metab. 88 (4): 1737-41. PMID 12679466. 
  • Patel FA, Funder JW, Challis JR (2003). "Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term.". J. Clin. Endocrinol. Metab. 88 (6): 2922-33. PMID 12788907. 
  • Nandy A, Jenatschke S, Hartung B, et al. (2004). "Genomic structure and transcriptional regulation of the human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene.". J. Mol. Endocrinol. 31 (1): 105-21. PMID 12914529.