HOXD1

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Homeobox D1
Identifiers
Symbol(s) HOXD1; HOX4; HOX4G; Hox-4.7
External IDs OMIM: 142987 MGI96201 HomoloGene7772
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 3231 15429
Ensembl ENSG00000128645 ENSMUSG00000042448
Uniprot Q9GZZ0 Q0VBQ9
Refseq NM_024501 (mRNA)
NP_078777 (protein)
NM_010467 (mRNA)
NP_034597 (protein)
Location Chr 2: 176.76 - 176.76 Mb Chr 2: 74.56 - 74.57 Mb
Pubmed search [1] [2]

Homeobox D1, also known as HOXD1, is a human gene.[1]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.[1]

Contents

[edit] See also

[edit] References

[edit] Further reading

  • Scott MP (1992). "Vertebrate homeobox gene nomenclature.". Cell 71 (4): 551–3. PMID 1358459. 
  • McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes.". Genomics 7 (3): 460. PMID 1973146. 
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652. 
  • Manohar CF, Salwen HR, Furtado MR, Cohn SL (1996). "Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation.". Tumour Biol. 17 (1): 34–47. PMID 7501971. 
  • Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins.". EMBO J. 13 (14): 3339–47. PMID 7913891. 
  • Manohar CF, Furtado MR, Salwen HR, Cohn SL (1993). "Hox gene expression in differentiating human neuroblastoma cells.". Biochem. Mol. Biol. Int. 30 (4): 733–41. PMID 8104620. 
  • Del Campo M, Jones MC, Veraksa AN, et al. (1999). "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster.". Am. J. Hum. Genet. 65 (1): 104–10. PMID 10364522. 
  • Adjaye J, Monk M (2000). "Transcription of homeobox-containing genes detected in cDNA libraries derived from human unfertilized oocytes and preimplantation embryos.". Mol. Hum. Reprod. 6 (8): 707–11. PMID 10908280. 
  • Limongi MZ, Pelliccia F, Gaddini L, Rocchi A (2000). "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1.". Cytogenet. Cell Genet. 90 (1-2): 151–3. PMID 11060466. 
  • Appukuttan B, Sood R, Ott S, et al. (2001). "Isolation and characterization of the human homeobox gene HOX D1.". Mol. Biol. Rep. 27 (4): 195–201. PMID 11455954. 
  • Pitera JE, Milla PJ, Scambler P, Adjaye J (2002). "Cloning of HOXD1 from unfertilised human oocytes and expression analyses during murine oogenesis and embryogenesis.". Mech. Dev. 109 (2): 377–81. PMID 11731253. 
  • Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.