HOXB6

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Homeobox B6
PDB rendering based on 1ahd.
Available structures: 1ahd, 1hom, 1san, 2hoa, 9ant
Identifiers
Symbol(s) HOXB6; HOX2; HOX2B; HU-2; Hox-2.2
External IDs OMIM: 142961 MGI: 96187 HomoloGene: 7366
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3216 15414
Ensembl ENSG00000108511 ENSMUSG00000000690
Uniprot P17509 P09023
Refseq NM_018952 (mRNA)
NP_061825 (protein)		 NM_008269 (mRNA)
NP_032295 (protein)
Location Chr 17: 44.03 - 44.04 Mb Chr 11: 96.12 - 96.12 Mb
Pubmed search [1] [2]

Homeobox B6, also known as HOXB6, is a human gene.[1]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: HOXB6 homeobox B6.

[edit] Further reading

  • Scott MP (1992). "Vertebrate homeobox gene nomenclature.". Cell 71 (4): 551-3. PMID 1358459. 
  • Kaur S, Singh G, Stock JL, et al. (1992). "Dominant mutation of the murine Hox-2.2 gene results in developmental abnormalities.". J. Exp. Zool. 264 (3): 323-36. doi:10.1002/jez.1402640311. PMID 1358998. 
  • Shen WF, Detmer K, Simonitch-Eason TA, et al. (1991). "Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues.". Nucleic Acids Res. 19 (3): 539-45. PMID 1672751. 
  • McAlpine PJ, Shows TB (1990). "Nomenclature for human homeobox genes.". Genomics 7 (3): 460. PMID 1973146. 
  • Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61-9. PMID 1981366. 
  • Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191-7. PMID 2570724. 
  • Shen WF, Largman C, Lowney P, et al. (1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines.". Proc. Natl. Acad. Sci. U.S.A. 86 (21): 8536-40. PMID 2573064. 
  • Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385-402. PMID 2574852. 
  • Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745-56. PMID 2576652. 
  • Murphy PD, Ferguson-Smith AC, Miki T, et al. (1987). "A moderately frequent RFLP identified by both SacI and BanII with a probe from the HOX2 locus in man (17q11-17q22).". Nucleic Acids Res. 15 (15): 6311. PMID 2888083. 
  • Levine M, Rubin GM, Tjian R (1984). "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.". Cell 38 (3): 667-73. PMID 6091895. 
  • Chang CP, Shen WF, Rozenfeld S, et al. (1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.". Genes Dev. 9 (6): 663-74. PMID 7729685. 
  • Castronovo V, Kusaka M, Chariot A, et al. (1994). "Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype.". Biochem. Pharmacol. 47 (1): 137-43. PMID 7906121. 
  • Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114-5. PMID 8646877. 
  • Sawcer S, Jones HB, Feakes R, et al. (1996). "A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22.". Nat. Genet. 13 (4): 464-8. doi:10.1038/ng0896-464. PMID 8696343. 
  • Zimmermann F, Rich IN (1997). "Mammalian homeobox B6 expression can be correlated with erythropoietin production sites and erythropoiesis during development, but not with hematopoietic or nonhematopoietic stem cell populations.". Blood 89 (8): 2723-35. PMID 9108390. 
  • Vider BZ, Zimber A, Hirsch D, et al. (1997). "Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression.". Biochem. Biophys. Res. Commun. 232 (3): 742-8. doi:10.1006/bbrc.1997.6364. PMID 9126347. 
  • Ohnishi K, Tobita T, Sinjo K, et al. (1999). "Modulation of homeobox B6 and B9 genes expression in human leukemia cell lines during myelomonocytic differentiation.". Leuk. Lymphoma 31 (5-6): 599-608. PMID 9922051. 
  • Fienberg AA, Nordstedt C, Belting HG, et al. (1999). "Phylogenetically conserved CK-II phosphorylation site of the murine homeodomain protein Hoxb-6.". J. Exp. Zool. 285 (1): 76-84. PMID 10327653. 
  • Vider BZ, Zimber A, Chastre E, et al. (2000). "Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines.". Biochem. Biophys. Res. Commun. 272 (2): 513-8. doi:10.1006/bbrc.2000.2804. PMID 10833444. 

[edit] External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD