Hot 100 number-one hits of 1959 (United States)
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These are the Billboard magazine Hot 100 number one hits of 1959.
| Issue Date | Song | Artist |
| January 5 | "The Chipmunk Song (Christmas Don't Be Late)" | David Seville and The Chipmunks |
| January 12 | "The Chipmunk Song (Christmas Don't Be Late)" | David Seville and The Chipmunks |
| January 19 | "Smoke Gets in Your Eyes" | The Platters |
| January 26 | "Smoke Gets in Your Eyes" | The Platters |
| February 2 | "Smoke Gets in Your Eyes" | The Platters |
| February 9 | "Stagger Lee" | Lloyd Price |
| February 16 | "Stagger Lee" | Lloyd Price |
| February 23 | "Stagger Lee" | Lloyd Price |
| March 2 | "Stagger Lee" | Lloyd Price |
| March 9 | "Venus" | Frankie Avalon |
| March 16 | "Venus" | Frankie Avalon |
| March 23 | "Venus" | Frankie Avalon |
| March 30 | "Venus" | Frankie Avalon |
| April 6 | "Venus" | Frankie Avalon |
| April 13 | "Come Softly to Me" | The Fleetwoods |
| April 20 | "Come Softly to Me" | The Fleetwoods |
| April 27 | "Come Softly to Me" | The Fleetwoods |
| May 4 | "Come Softly to Me" | The Fleetwoods |
| May 11 | "The Happy Organ" | Dave "Baby" Cortez |
| May 18 | "Kansas City" | Wilbert Harrison |
| May 25 | "Kansas City" | Wilbert Harrison |
| June 1 | "The Battle of New Orleans" | Johnny Horton |
| June 8 | "The Battle of New Orleans" | Johnny Horton |
| June 15 | "The Battle of New Orleans" | Johnny Horton |
| June 22 | "The Battle of New Orleans" | Johnny Horton |
| June 29 | "The Battle of New Orleans" | Johnny Horton |
| July 6 | "The Battle of New Orleans" | Johnny Horton |
| July 13 | "Lonely Boy" | Paul Anka |
| July 20 | "Lonely Boy" | Paul Anka |
| July 27 | "Lonely Boy" | Paul Anka |
| August 3 | "Lonely Boy" | Paul Anka |
| August 10 | "A Big Hunk o' Love" | Elvis Presley |
| August 17 | "A Big Hunk o' Love" | Elvis Presley |
| August 24 | "The Three Bells" | The Browns |
| August 31 | "The Three Bells" | The Browns |
| September 7 | "The Three Bells" | The Browns |
| September 14 | "The Three Bells" | The Browns |
| September 21 | "Sleep Walk" | Santo & Johnny |
| September 28 | "Sleep Walk" | Santo & Johnny |
| October 5 | "Mack the Knife" | Bobby Darin |
| October 12 | "Mack the Knife" | Bobby Darin |
| October 19 | "Mack the Knife" | Bobby Darin |
| October 26 | "Mack the Knife" | Bobby Darin |
| November 2 | "Mack the Knife" | Bobby Darin |
| November 9 | "Mack the Knife" | Bobby Darin |
| November 16 | "Mr. Blue" | The Fleetwoods |
| November 23 | "Mack the Knife" | Bobby Darin |
| November 30 | "Mack the Knife" | Bobby Darin |
| December 7 | "Mack the Knife" | Bobby Darin |
| December 14 | "Heartaches by the Number" | Guy Mitchell |
| December 21 | "Heartaches by the Number" | Guy Mitchell |
| December 28 | "Why" | Frankie Avalon |
