Homospermidine synthase (spermidine-specific)

From Wikipedia, the free encyclopedia

In enzymology, a homospermidine synthase (spermidine-specific) (EC 2.5.1.45) is an enzyme that catalyzes the chemical reaction

spermidine + putrescine $\rightleftharpoons$ sym-homospermidine + propane-1,3-diamine

Thus, the two substrates of this enzyme are spermidine and putrescine, whereas its two products are sym-homospermidine and propane-1,3-diamine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming).

[edit] References

IUBMB entry for 2.5.1.45
BRENDA references for 2.5.1.45 (Recommended.)
PubMed references for 2.5.1.45
PubMed Central references for 2.5.1.45
Google Scholar references for 2.5.1.45
Ostrovsky AN, Grischenko AV, Taylor PD, Bock P, Mawatari SF (2006). "Comparative anatomical study of internal brooding in three anascan bryozoans (Cheilostomata) and its taxonomic and evolutionary implications". J. Morphol. 267: 739–49. doi:10.1002/jmor.10438. PMID 16526057.
Ober D, Hartmann T (1999). "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proc. Natl. Acad. Sci. U. S. A. 96: 14777–82. doi:10.1073/pnas.96.26.14777. PMID 10611289.
Ober D, Harms R and Hartmann T (2000). "Cloning and expression of homospermidine synthase from Senecio vulgaris: a revision". Phytochemistry 55: 311–316.