Homoserine O-succinyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a homoserine O-succinyltransferase (EC 2.3.1.46) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + L-homoserine CoA + O-succinyl-L-homoserine

Thus, the two substrates of this enzyme are succinyl-CoA and L-homoserine, whereas its two products are CoA and O-succinyl-L-homoserine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:L-homoserine O-succinyltransferase. Other names in common use include homoserine O-transsuccinylase, and homoserine succinyltransferase. This enzyme participates in methionine metabolism and sulfur metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2GHR and 2H2W.

[edit] References

• IUBMB entry for 2.3.1.46
• BRENDA references for 2.3.1.46 (Recommended.)
• PubMed references for 2.3.1.46
• PubMed Central references for 2.3.1.46
• Google Scholar references for 2.3.1.46
• Rowbury RJ and Woods DD (1964). "O-Succinylhomoserine as an intermediate in the synthesis of cystathionine by Escherichia coli". J. Gen. Microbiol. 36: 341–358. 

[edit] External links

The CAS registry number for this enzyme class is 62213-51-8.

• IUBMB entry for 2.3.1.46

• KEGG entry for 2.3.1.46

• BRENDA entry for 2.3.1.46

• NiceZyme view of 2.3.1.46

• EC2PDB: PDB structures for 2.3.1.46

• PRIAM entry for 2.3.1.46

• PUMA2 entry for 2.3.1.46

• IntEnz: Integrated Enzyme entry for 2.3.1.46

• MetaCyc entry for 2.3.1.46

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008899: homoserine O-succinyltransferase

• AMIGO entry for GO code 0008899: homoserine O-succinyltransferase