Homoglutathione synthase

From Wikipedia, the free encyclopedia

In enzymology, a homoglutathione synthase (EC 6.3.2.23) is an enzyme that catalyzes the chemical reaction

ATP + gamma-L-glutamyl-L-cysteine + beta-alanine ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine

The 3 substrates of this enzyme are ATP, gamma-L-glutamyl-L-cysteine, and beta-alanine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamyl-L-cysteinyl-beta-alanine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming). Other names in common use include homoglutathione synthetase, and beta-alanine specific hGSH synthetase.

[edit] References

• IUBMB entry for 6.3.2.23
• BRENDA references for 6.3.2.23 (Recommended.)
• PubMed references for 6.3.2.23
• PubMed Central references for 6.3.2.23
• Google Scholar references for 6.3.2.23
• Macnicol PK (1987). "Homoglutathione and glutathione synthetases of legume seedlings - partial-purification and substrate-specificity". Plant Sci. 53: 229–235. doi:10.1016/0168-9452(87)90159-2. 

[edit] External links

The CAS registry number for this enzyme class is 113875-72-2.

• IUBMB entry for 6.3.2.23

• KEGG entry for 6.3.2.23

• BRENDA entry for 6.3.2.23

• NiceZyme view of 6.3.2.23

• EC2PDB: PDB structures for 6.3.2.23

• PRIAM entry for 6.3.2.23

• PUMA2 entry for 6.3.2.23

• IntEnz: Integrated Enzyme entry for 6.3.2.23

• MetaCyc entry for 6.3.2.23

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047983: homoglutathione synthase

• AMIGO entry for GO code 0047983: homoglutathione synthase