HOMER3

From Wikipedia, the free encyclopedia

Homer homolog 3 (Drosophila)

Identifiers

HOMER3; HOMER-3

External IDs

OMIM: 604800 MGI: 1347359 HomoloGene: 37972

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• cellular_component
Biological Process:	• protein targeting • metabotropic glutamate receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004838 (mRNA)
NP_004829 (protein)

NM_011984 (mRNA)
NP_036114 (protein)

Location

Chr 19: 18.9 - 18.91 Mb

Chr 8: 73.21 - 73.22 Mb

Pubmed search

[1]

[2]

Homer homolog 3 (Drosophila), also known as HOMER3, is a human gene.^[1]

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth.^[1]

[edit] References

^ ^a ^b Entrez Gene: HOMER3 homer homolog 3 (Drosophila).

[edit] Further reading

Brakeman PR, Lanahan AA, O'Brien R, et al. (1997). "Homer: a protein that selectively binds metabotropic glutamate receptors.". Nature 386 (6622): 284–8. doi:10.1038/386284a0. PMID 9069287.
Xiao B, Tu JC, Petralia RS, et al. (1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.". Neuron 21 (4): 707–16. PMID 9808458.
Tu JC, Xiao B, Yuan JP, et al. (1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.". Neuron 21 (4): 717–26. PMID 9808459.
Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing.". J. Mol. Biol. 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.
Feng W, Tu J, Yang T, et al. (2003). "Homer regulates gain of ryanodine receptor type 1 channel complex.". J. Biol. Chem. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yuan JP, Kiselyov K, Shin DM, et al. (2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.". Cell 114 (6): 777–89. PMID 14505576.
Ishiguro K, Xavier R (2004). "Homer-3 regulates activation of serum response element in T cells via its EVH1 domain.". Blood 103 (6): 2248–56. doi:10.1182/blood-2003-08-2671. PMID 14645007.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Cooper ST, Hanson IM (2006). "A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11.". BMC Genet. 6: 43. doi:10.1186/1471-2156-6-43. PMID 16098226.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Schreiner D, Müller K, Hofer HW (2006). "The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins.". FEBS Lett. 580 (22): 5295–300. doi:10.1016/j.febslet.2006.08.079. PMID 16979624.