HOMER2

From Wikipedia, the free encyclopedia

Homer homolog 2 (Drosophila)

PDB rendering based on 1i7a.

Available structures: 1i7a

Identifiers

Symbol(s)

HOMER2; CPD; ACPD; HOMER-2; HOMER2A; HOMER2B; Vesl-2

External IDs

OMIM: 604799 MGI: 1347354 HomoloGene: 3560

Gene ontology
Molecular Function:	• actin binding • protein binding • GKAP/Homer scaffold activity
Cellular Component:	• cytoplasm
Biological Process:	• metabotropic glutamate receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004839 (mRNA)
NP_004830 (protein)

NM_011983 (mRNA)
NP_036113 (protein)

Location

Chr 15: 81.31 - 81.35 Mb

Chr 7: 81.48 - 81.52 Mb

Pubmed search

[1]

[2]

Homer homolog 2 (Drosophila), also known as HOMER2, is a human gene.^[1]

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth. Four transcript variants encoding distinct isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: HOMER2 homer homolog 2 (Drosophila).

[edit] Further reading

Xiao B, Tu JC, Petralia RS, et al. (1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.". Neuron 21 (4): 707–16. PMID 9808458.
Tu JC, Xiao B, Yuan JP, et al. (1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.". Neuron 21 (4): 717–26. PMID 9808459.
Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing.". J. Mol. Biol. 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.
Feng W, Tu J, Yang T, et al. (2003). "Homer regulates gain of ryanodine receptor type 1 channel complex.". J. Biol. Chem. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.
Kim JT, Park SH, Kim SK, et al. (2003). "Potential role of Homer-2a on cutaneous vascular anomaly.". J. Korean Med. Sci. 17 (5): 636–40. PMID 12378015.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Shiraishi Y, Mizutani A, Mikoshiba K, Furuichi T (2003). "Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons.". Mol. Cell. Neurosci. 22 (2): 188–201. PMID 12676529.
Rong R, Ahn JY, Huang H, et al. (2003). "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.". Nat. Neurosci. 6 (11): 1153–61. doi:10.1038/nn1134. PMID 14528310.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ishibashi T, Ogawa S, Hashiguchi Y, et al. (2005). "A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems.". J. Biochem. 137 (5): 617–23. doi:10.1093/jb/mvi074. PMID 15944415.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Dahl JP, Kampman KM, Oslin DW, et al. (2006). "Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population.". Psychiatr. Genet. 15 (4): 277–83. PMID 16314758.