Holo-ACP synthase
From Wikipedia, the free encyclopedia
In enzymology, a holo-ACP synthase (EC 2.7.7.61) is an enzyme that catalyzes the chemical reaction
- 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA + apo-citrate lyase
holo-citrate lyase + diphosphate
Thus, the two substrates of this enzyme are [[2'-(5-triphosphoribosyl)-3'-dephospho-CoA]] and apo-citrate lyase, whereas its two products are holo-citrate lyase and diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is 2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase. Other names in common use include 2'-(5"-phosphoribosyl)-3'-dephospho-CoA transferase, 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase, and CitX. This enzyme participates in two-component system - general.
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[edit] Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2BDD.
[edit] References
- IUBMB entry for 2.7.7.61
- BRENDA references for 2.7.7.61 (Recommended.)
- PubMed references for 2.7.7.61
- PubMed Central references for 2.7.7.61
- Google Scholar references for 2.7.7.61
- Schneider K, Dimroth P, Bott M (2000). "Biosynthesis of the prosthetic group of citrate lyase". Biochemistry. 39: 9438–50. doi:. PMID 10924139.
- Schneider K, Dimroth P, Bott M (2000). "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group". FEBS. Lett. 483: 165–8. doi:. PMID 11042274.
[edit] External links
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- The CAS registry number for this enzyme class is 312492-44-7.
[edit] Gene Ontology (GO) codes
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