Holo-(acyl-carrier-protein) synthase

From Wikipedia, the free encyclopedia

In enzymology, a holo-[acyl-carrier-protein] synthase (EC 2.7.8.7) is an enzyme that catalyzes the chemical reaction:

CoA-[4'-phosphopantetheine] + apo-acyl carrier protein $\rightleftharpoons$ adenosine 3',5'-bisphosphate + holo-acyl carrier protein

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CoA-[4'-phosphopantetheine]:apo-[acyl-carrier-protein] 4'-pantetheinephosphotransferase. Other names in common use include acyl carrier protein holoprotein (holo-ACP) synthetase, holo-ACP synthetase, coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine, transferase, holosynthase, acyl carrier protein synthetase, holo-ACP synthase, PPTase, AcpS, ACPS, acyl carrier protein synthase, P-pant transferase, and CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase. This enzyme participates in pantothenate and coa biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1F7L, 1F7T, 1F80, 1FTE, 1FTF, 1FTH, 2JBZ, and 2JCA.

[edit] References

IUBMB entry for 2.7.8.7
BRENDA references for 2.7.8.7 (Recommended.)
PubMed references for 2.7.8.7
PubMed Central references for 2.7.8.7
Google Scholar references for 2.7.8.7
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Reid R, Khosla C, Walsh CT (1996). "A new enzyme superfamily - the phosphopantetheinyl transferases". Chem. Biol. 3: 923–36. doi:10.1016/S1074-5521(96)90181-7. PMID 8939709.
Walsh CT, Gehring AM, Weinreb PH, Quadri LE, Flugel RS (1997). "Post-translational modification of polyketide and nonribosomal peptide synthases". Curr. Opin. Chem. Biol. 1: 309–15. doi:10.1016/S1367-5931(97)80067-1. PMID 9667867.
Mootz HD, Finking R, Marahiel MA (2001). "4'-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis". J. Biol. Chem. 276: 37289–98. doi:10.1074/jbc.M103556200. PMID 11489886.
Joshi AK, Zhang L, Rangan VS, Smith S (2003). "Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity". J. Biol. Chem. 278: 33142–9. doi:10.1074/jbc.M305459200. PMID 12815048.