HNT

From Wikipedia, the free encyclopedia

Neurotrimin

Identifiers

HNT; MGC60329; NTM

External IDs

OMIM: 607938 MGI: 2446259 HomoloGene: 41139

Gene ontology
Molecular Function:	• protein binding • GPI anchor binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cell adhesion • neuron recognition

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001048209 (mRNA)
NP_001041674 (protein)

NM_172290 (mRNA)
NP_758494 (protein)

Location

Chr 11: 130.75 - 131.71 Mb

Chr 9: 28.75 - 29.71 Mb

Pubmed search

[1]

[2]

Neurotrimin, also known as HNT, is a human gene.^[1]

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple alternatively spliced variants have been found but only two variants have had their full-length sequences determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: HNT neurotrimin.

[edit] Further reading

Struyk AF, Canoll PD, Wolfgang MJ, et al. (1995). "Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules.". J. Neurosci. 15 (3 Pt 2): 2141-56. PMID 7891157.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205-20. PMID 12107410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sellar GC, Watt KP, Rabiasz GJ, et al. (2003). "OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer.". Nat. Genet. 34 (3): 337-43. doi:10.1038/ng1183. PMID 12819783.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
Liu J, Li G, Peng X, et al. (2004). "The cloning and preliminarily functional analysis of the human neurotrimin gene.". Sci. China, C, Life Sci. 47 (2): 158-64. PMID 15379248.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.