HNRNPC

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Heterogeneous nuclear ribonucleoprotein C (C1/C2)
PDB rendering based on 1wf2.
Available structures: 1wf2
Identifiers
Symbol(s) HNRPC; C1; C2; HNRNP; MGC104306; MGC105117; MGC117353; MGC131677; SNRPC; hnRNPC
External IDs OMIM: 164020 MGI: 107795 HomoloGene: 74524
Orthologs
Human Mouse
Entrez 3183 15381
Ensembl n/a ENSMUSG00000060373
Uniprot n/a Q3U6P5
Refseq NM_001077442 (mRNA)
NP_001070910 (protein)		 NM_016884 (mRNA)
NP_058580 (protein)
Location n/a Chr 14: 51 - 51.03 Mb
Pubmed search [1] [2]

Heterogeneous nuclear ribonucleoprotein C (C1/C2), also known as HNRPC, is a human gene.[1]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: HNRPC heterogeneous nuclear ribonucleoprotein C (C1/C2).

[edit] Further reading

  • Görlach M, Wittekind M, Beckman RA, et al. (1992). "Interaction of the RNA-binding domain of the hnRNP C proteins with RNA.". EMBO J. 11 (9): 3289–95. PMID 1380452. 
  • Wittekind M, Görlach M, Friedrichs M, et al. (1992). "1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins.". Biochemistry 31 (27): 6254–65. PMID 1385725. 
  • Burd CG, Swanson MS, Görlach M, Dreyfuss G (1990). "Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 9788–92. PMID 2557628. 
  • Merrill BM, Barnett SF, LeStourgeon WM, Williams KR (1989). "Primary structure differences between proteins C1 and C2 of HeLa 40S nuclear ribonucleoprotein particles.". Nucleic Acids Res. 17 (21): 8441–9. PMID 2587210. 
  • Swanson MS, Nakagawa TY, LeVan K, Dreyfuss G (1987). "Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins.". Mol. Cell. Biol. 7 (5): 1731–9. PMID 3110598. 
  • Nakagawa TY, Swanson MS, Wold BJ, Dreyfuss G (1986). "Molecular cloning of cDNA for the nuclear ribonucleoprotein particle C proteins: a conserved gene family.". Proc. Natl. Acad. Sci. U.S.A. 83 (7): 2007–11. PMID 3457372. 
  • Sébillon P, Beldjord C, Kaplan JC, et al. (1995). "A T to G mutation in the polypyrimidine tract of the second intron of the human beta-globin gene reduces in vitro splicing efficiency: evidence for an increased hnRNP C interaction.". Nucleic Acids Res. 23 (17): 3419–25. PMID 7567451. 
  • Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. PMID 7821789. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Huang M, Rech JE, Northington SJ, et al. (1994). "The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles.". Mol. Cell. Biol. 14 (1): 518–33. PMID 8264621. 
  • Hamilton BJ, Nagy E, Malter JS, et al. (1993). "Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences.". J. Biol. Chem. 268 (12): 8881–7. PMID 8473331. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Romero F, Ramos-Morales F, Domínguez A, et al. (1998). "Grb2 and its apoptotic isoform Grb3-3 associate with heterogeneous nuclear ribonucleoprotein C, and these interactions are modulated by poly(U) RNA.". J. Biol. Chem. 273 (13): 7776–81. PMID 9516488. 
  • Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. 
  • Sella O, Gerlitz G, Le SY, Elroy-Stein O (1999). "Differentiation-induced internal translation of c-sis mRNA: analysis of the cis elements and their differentiation-linked binding to the hnRNP C protein.". Mol. Cell. Biol. 19 (8): 5429–40. PMID 10409733. 
  • Wang W, Furneaux H, Cheng H, et al. (2000). "HuR regulates p21 mRNA stabilization by UV light.". Mol. Cell. Biol. 20 (3): 760–9. PMID 10629032. 
  • Spångberg K, Wiklund L, Schwartz S (2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities.". Virology 274 (2): 378–90. doi:10.1006/viro.2000.0461. PMID 10964780. 
  • Shahied L, Braswell EH, LeStourgeon WM, Krezel AM (2001). "An antiparallel four-helix bundle orients the high-affinity RNA binding sites in hnRNP C: a mechanism for RNA chaperonin activity.". J. Mol. Biol. 305 (4): 817–28. doi:10.1006/jmbi.2000.4331. PMID 11162094. 
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298. 
  • Stone JR, Collins T (2002). "Rapid phosphorylation of heterogeneous nuclear ribonucleoprotein C1/C2 in response to physiologic levels of hydrogen peroxide in human endothelial cells.". J. Biol. Chem. 277 (18): 15621–8. doi:10.1074/jbc.M112153200. PMID 11877401. 
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