HNRNPA0

From Wikipedia, the free encyclopedia

Heterogeneous nuclear ribonucleoprotein A0

Identifiers

HNRPA0; hnRNPA0

External IDs

OMIM: 609409 MGI: 1924384 HomoloGene: 74582

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding
Cellular Component:	• nucleus • heterogeneous nuclear ribonucleoprotein complex
Biological Process:	• mRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_006805 (mRNA)
NP_006796 (protein)

XM_001001311 (mRNA)
XP_001001311 (protein)

Location

Chr 5: 137.12 - 137.12 Mb

Chr 13: 58.14 - 58.14 Mb

Pubmed search

[1]

[2]

Heterogeneous nuclear ribonucleoprotein A0, also known as HNRPA0, is a human gene.^[1]

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus.^[1]

[edit] References

^ ^a ^b Entrez Gene: HNRPA0 heterogeneous nuclear ribonucleoprotein A0.

[edit] Further reading

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Myer VE, Steitz JA (1995). "Isolation and characterization of a novel, low abundance hnRNP protein: A0.". RNA 1 (2): 171–82. PMID 7585247.
Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column.". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
Li SH, McInnis MG, Margolis RL, et al. (1993). "Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms.". Genomics 16 (3): 572–9. doi:10.1006/geno.1993.1232. PMID 8325628.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Lai F, Godley LA, Joslin J, et al. (2001). "Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q).". Genomics 71 (2): 235–45. doi:10.1006/geno.2000.6414. PMID 11161817.
Rousseau S, Morrice N, Peggie M, et al. (2003). "Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.". EMBO J. 21 (23): 6505–14. PMID 12456657.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.". Nat. Methods 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174.