HMGN3

From Wikipedia, the free encyclopedia

High mobility group nucleosomal binding domain 3

Identifiers

HMGN3; DKFZp686E20226; PNAS-24; PNAS-25; TRIP7

External IDs

OMIM: 604502 MGI: 2138069 HomoloGene: 3130

Gene ontology
Molecular Function:	• DNA binding • chromatin binding • thyroid hormone receptor binding
Cellular Component:	• chromatin • nucleus
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004242 (mRNA)
NP_004233 (protein)

NM_026122 (mRNA)
NP_080398 (protein)

Location

Chr 6: 79.97 - 80 Mb

Chr 9: 82.91 - 82.92 Mb

Pubmed search

[1]

[2]

High mobility group nucleosomal binding domain 3, also known as HMGN3, is a human gene.^[1]

Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: HMGN3 high mobility group nucleosomal binding domain 3.

[edit] Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Leong PW, Liew K, Lim W, Chow VT (2002). "Differential display RT-PCR analysis of enterovirus-71-infected rhabdomyosarcoma cells reveals mRNA expression responses of multiple human genes with known and novel functions.". Virology 295 (1): 147-59. doi:10.1006/viro.2002.1353. PMID 12033773.
West KL, Ito Y, Birger Y, et al. (2001). "HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome-binding proteins.". J. Biol. Chem. 276 (28): 25959-69. doi:10.1074/jbc.M101692200. PMID 11356838.
Lee JW, Choi HS, Gyuris J, et al. (1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.". Mol. Endocrinol. 9 (2): 243-54. PMID 7776974.