HMGB1

From Wikipedia, the free encyclopedia

High-mobility group box 1

PDB rendering based on 1aab.

Available structures: 1aab, 1ckt, 1hme, 1hmf, 1hsm, 1hsn, 1j3x, 1nhm, 1nhn

Identifiers

Symbol(s)

HMGB1; DKFZp686A04236; HMG1; HMG3; SBP-1

External IDs

OMIM: 163905 MGI: 96113 HomoloGene: 55511

Gene ontology
Molecular Function:	• DNA binding • transcription factor binding • DNA bending activity
Cellular Component:	• chromatin • condensed chromosome • nucleus
Biological Process:	• DNA unwinding during replication • DNA repair • base-excision repair, DNA ligation • DNA recombination • establishment and/or maintenance of chromatin architecture • regulation of transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • anti-apoptosis • signal transduction • negative regulation of transcriptional preinitiation complex assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002128 (mRNA)
NP_002119 (protein)

NM_010439 (mRNA)
NP_034569 (protein)

Location

Chr 13: 29.93 - 30.09 Mb

n/a

Pubmed search

[1]

[2]

High-mobility group box 1, also known as HMGB1 and Amphoterin, is a human gene and protein that belongs to high mobility group.

[edit] Further reading

Thomas JO, Travers AA (2001). "HMG1 and 2, and related 'architectural' DNA-binding proteins.". Trends Biochem. Sci. 26 (3): 167-74. PMID 11246022.
Andersson U, Erlandsson-Harris H, Yang H, Tracey KJ (2003). "HMGB1 as a DNA-binding cytokine.". J. Leukoc. Biol. 72 (6): 1084-91. PMID 12488489.
Erlandsson Harris H, Andersson U (2004). "Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator.". Eur. J. Immunol. 34 (6): 1503-12. doi:10.1002/eji.200424916. PMID 15162419.
Jiang W, Pisetsky DS (2007). "Mechanisms of Disease: the role of high-mobility group protein 1 in the pathogenesis of inflammatory arthritis.". Nature clinical practice. Rheumatology 3 (1): 52-8. doi:10.1038/ncprheum0379. PMID 17203009.
Ellerman JE, Brown CK, de Vera M, et al. (2007). "Masquerader: high mobility group box-1 and cancer.". Clin. Cancer Res. 13 (10): 2836-48. doi:10.1158/1078-0432.CCR-06-1953. PMID 17504981.
Fossati S, Chiarugi A (2007). "Relevance of high-mobility group protein box 1 to neurodegeneration.". Int. Rev. Neurobiol. 82: 137-48. doi:10.1016/S0074-7742(07)82007-1. PMID 17678959.
Parkkinen J, Rauvala H (1991). "Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin. Enhancement of t-PA-catalyzed plasminogen activation by amphoterin.". J. Biol. Chem. 266 (25): 16730-5. PMID 1909331.
Wen L, Huang JK, Johnson BH, Reeck GR (1989). "A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.". Nucleic Acids Res. 17 (3): 1197-214. PMID 2922262.
Bernués J, Espel E, Querol E (1986). "Identification of the core-histone-binding domains of HMG1 and HMG2.". Biochim. Biophys. Acta 866 (4): 242-51. PMID 3697355.
Ge H, Roeder RG (1994). "The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein.". J. Biol. Chem. 269 (25): 17136-40. PMID 8006019.
Parkkinen J, Raulo E, Merenmies J, et al. (1993). "Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation.". J. Biol. Chem. 268 (26): 19726-38. PMID 8366113.
Ferrari S, Finelli P, Rocchi M, Bianchi ME (1996). "The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13.". Genomics 35 (2): 367-71. doi:10.1006/geno.1996.0369. PMID 8661151.
Zappavigna V, Falciola L, Helmer-Citterich M, et al. (1996). "HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation.". EMBO J. 15 (18): 4981-91. PMID 8890171.
Xiang YY, Wang DY, Tanaka M, et al. (1997). "Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa.". Int. J. Cancer 74 (1): 1-6. PMID 9036861.
Rasmussen RK, Ji H, Eddes JS, et al. (1997). "Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.". Electrophoresis 18 (3-4): 588-98. doi:10.1002/elps.1150180342. PMID 9150946.
Jayaraman L, Moorthy NC, Murthy KG, et al. (1998). "High mobility group protein-1 (HMG-1) is a unique activator of p53.". Genes Dev. 12 (4): 462-72. PMID 9472015.
Milev P, Chiba A, Häring M, et al. (1998). "High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule.". J. Biol. Chem. 273 (12): 6998-7005. PMID 9507007.
Nagaki S, Yamamoto M, Yumoto Y, et al. (1998). "Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks.". Biochem. Biophys. Res. Commun. 246 (1): 137-41. doi:10.1006/bbrc.1998.8589. PMID 9600082.
Claudio JO, Liew CC, Dempsey AA, et al. (1999). "Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy.". Genomics 50 (1): 44-52. doi:10.1006/geno.1998.5308. PMID 9628821.
Boonyaratanakornkit V, Melvin V, Prendergast P, et al. (1998). "High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells.". Mol. Cell. Biol. 18 (8): 4471-87. PMID 9671457.