HLA-DRB1

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See also: HLA-DR

Major histocompatibility complex, class II, DR beta 1
PDB rendering based on 1aqd.
Available structures: 1aqd, 1bx2, 1d5m, 1d5x, 1d5z, 1d6e, 1dlh, 1fv1, 1fyt, 1h15, 1hqr, 1hxy, 1j8h, 1jwm, 1jws, 1jwu, 1kg0, 1klg, 1klu, 1lo5, 1pyw, 1r5i, 1seb, 1sje, 1sjh, 1t5w, 1t5x, 1ymm, 1zgl, 2fse, 2g9h, 2iam, 2ian, 2icw, 2ipk, 2oje, 2seb
Identifiers
Symbol(s)	HLA-DRB1; DRB1; HLA DRB1; HLA-DR1B
External IDs	OMIM: 142857 MGI: 95901 HomoloGene: 85991
Gene ontology Molecular Function: • MHC class II receptor activity Cellular Component: • membrane • integral to membrane • MHC class II protein complex Biological Process: • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • immune response
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3123	14969
Ensembl	ENSG00000196126	ENSMUSG00000060586
Uniprot	P01911	O19450
Refseq	NM_002124 (mRNA) NP_002115 (protein)	NM_010382 (mRNA) NP_034512 (protein)
Location	Chr 6: 32.65 - 32.67 Mb	Chr 17: 33.91 - 33.92 Mb
Pubmed search	[1]	[2]

Major histocompatibility complex, class II, DR beta 1, also known as HLA-DRB1, is a human gene.

HLA-DRB1 belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.^[1]

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