HLA-DR14

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR14
Haplotypes groups DRA*01:DRB1*1401 DRA*01:DRB1*1402 DRA*01:DRB1*1403 DRA*01:DRB1*1404 ....
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *1401 to *1408 *1410
Symbol(s) HLA-DRB1
EBI-HLA DRB1*1401
EBI-HLA DRB1*1402
EBI-HLA DRB1*1403
EBI-HLA DRB1*1404
EBI-HLA DRB1*1405
EBI-HLA DRB1*1406
Shared data
Locus chr.6 6p21.31

HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.

Contents

[edit] Alleles

DR14, DR6 and other serotype recognition of some DRB1*14 alleles[1]
DRB1* DR14 DR6 DR13 Sample
allele  %  %  % size (N)
1401 74 14 3 1942
1402 61 13 9 204
1403 72 12 2 37
1404 79 8 80[2]
1405 86 10 58
1406 37 15 22 117
1407 90 10
1408 25 4

[3]
1410 >75 4

Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462

[edit] Disease associations

DRB1*1402: juvenile rheumatoid arthritis[4], increased longevity in Okinawans.


[edit] Extended linkage

DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.[5]

[edit] Genetic Linkage

DR14 Haplotypes
DRA DRB1 DRB3
DR14(6)-DR52 *0101 *1401 *0201
*0101 *1402 *0201
*0101 *1403 *0101
DQA1 DQB1 DRB1
DR14-DQ5(5.3, 1) *0104 *0503 *1401
HLA-A HLA-B DRB1
A11-B35-DR14(6) *1101 *3501 *1401
A2-B51(5)-DR14(6) *0201 *5101 *1401

HLA-DR13 is genetically linked to HLA-DR52[6] and HLA-DQ5 (HLA-DQ1) serotypes.

[edit] References

  1. ^ derived from IMGT/HLA
  2. ^ DR1404 - 3%
  3. ^ DR4 - 25%
  4. ^ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos.". Hum Immunol 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191. 
  5. ^ Niks EH, Kuks JB, Roep BO, et al (2006). "Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5". Neurology 66 (11): 1772–4. doi:10.1212/01.wnl.0000218159.79769.5c. PMID 16769963. 
  6. ^ Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol. 65 (3): 270–6. doi:10.1016/j.humimm.2003.12.005. PMID 15041167. 
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HLA DR serotypes

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