HLA-DR10

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR10
Haplotypes groups DQA*01:DRB1*1001
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *1001
Symbol(s) HLA-DRB1
EBI-HLA DRB1*1001
Shared data
Locus chr.6 6p21.31

HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.

Contents

[edit] Serology

DR10 serotype recognition of the DRB1*1001 allele gene product[1]
DRB1* DR10 DR1 Sample
allele  %  %  % size (N)
1001 90 4 894

The serological reaction of DR10 is relatively good.

[edit] Disease associations

[edit] By serotpye

DR10 sertoype or cognate alleles are associated with: Lichen planus[2]

[edit] By allele

DRB1*1001 is associated with ovarian cancer[3] and invasive squamous cell cervical cancer (SCC)[4]

[edit] Extended linkage

DRB1*1001:DQA1*01:DQB1*05 haplotype: Rheumatoid arthritis[5] The primary involvement appears to be DR10.

[edit] Genetic Linkage

DR10 Haplotypes
DRA DRB1
Haplotypes *0101 *1001
DQA1 DQB1 DRB1
Haplotypes *0101 *0501 *1001
HLA-A HLA-B DRB1
Haplotypes *0000 *0000 *1001

HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. One haplotype found in caucasions is the HLA-A1-B37-Cw6-DR10-DQ5.

[edit] References

  1. ^ derived from IMGT/HLA
  2. ^ White A, Rostom A (1994). "HLA antigens in Arabs with lichen planus.". Clin Exp Dermatol 19 (3): 236–7. doi:10.1111/j.1365-2230.1994.tb01174.x. PMID 8033385. 
  3. ^ Kübler K, Arndt P, Wardelmann E, Krebs D, Kuhn W, van der Ven K (2006). "HLA-class II haplotype associations with ovarian cancer.". Int J Cancer 119 (12): 2980–5. doi:10.1002/ijc.22266. PMID 17016821. 
  4. ^ Madeleine M, Brumback B, Cushing-Haugen K, Schwartz S, Daling J, Smith A, Nelson J, Porter P, Shera K, McDougall J, Galloway D (2002). "Human leukocyte antigen class II and cervical cancer risk: a population-based study.". J Infect Dis 186 (11): 1565–74. doi:10.1086/345285. PMID 12447731. 
  5. ^ Pascual M, Nieto A, López-Nevot M, Ramal L, Matarán L, Caballero A, Alonso A, Martín J, Zanelli E (2001). "Rheumatoid arthritis in southern Spain: toward elucidation of a unifying role of the HLA class II region in disease predisposition.". Arthritis Rheum 44 (2): 307–14. doi:10.1002/1529-0131(200102)44:2<307::AID-ANR47>3.0.CO;2-K. PMID 11229460. 
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HLA DR serotypes

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