HLA-DQB1

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Major histocompatibility complex, class II, DQ beta 1
Available structures: 1jk8, 1s9v
Identifiers
Symbol(s)	HLA-DQB1; CELIAC1; HLA-DQB; IDDM1
External IDs	OMIM: 604305
Gene ontology Molecular Function: • GTP binding • MHC class II receptor activity Cellular Component: • membrane • integral to membrane • MHC class II protein complex Biological Process: • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • immune response • cell cycle
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3119	n/a
Ensembl	ENSG00000206237	n/a
Uniprot	P01918	n/a
Refseq	NM_002123 (mRNA) NP_002114 (protein)	n/a (mRNA) n/a (protein)
Location	Chr c6_COX: 32.7 - 32.7 Mb	n/a
Pubmed search	[1]	n/a

Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene.

HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.^[1]

[edit] See also

• Major histocompatibility complex
• Human leukocyte antigen
• HLA-DQ

[edit] References

[edit] Further reading