HLA-DM

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HLA-DM is an intracellular protein involved in peptide presentation by MHC class II. It is encoded by the genes HLA-DMA and HLA-DMB.

In the endosomes, HLA-DM functions by promoting the dissociation of the CLIP peptide (a place holder peptide) from MHC class II which allows endosomal peptides to bind. Possibly by its preferential binding of the open, peptide-less conformation of MHC class II, HLA-DM then catalyzes peptide exchange, favoring more stable peptide-MHC complexes (which are resistant to DM action). Thus, HLA-DM is thought to play an important role in "editing" the peptide repertoire.

[edit] External links

• Overview at Davidson College (student generated)
• Busch R, Rinderknecht CH, Roh S, Lee AW, Harding JJ, Burster T, Hornell TM, Mellins ED. Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression. Immunol Rev. 2005 207:242-60. PMID 16181341