HLA-B7

From Wikipedia, the free encyclopedia

major histocompatibility complex (human), class I, B7
Alleles B*0702, *0703, *0704, *0705
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*0702
EBI-HLA B*0703
EBI-HLA B*0704
EBI-HLA B*0705
Locus chr.6 6p21.31

HLA-B7 (B7) is an HLA-B serotype. The serotype identifies the more common HLA-B*07 gene products.[1] (For terminology help see: HLA-serotype tutorial) B7, previously HL-A7, was one of the first 'HL-A' antigens recognized, largely because of the frequency of B*0702 in Northern and Western Europe and the United States. B7 is found in two major haplotypes in Europe, where it reaches peak frequency in Ireland. One haplotype A3-B7-DR15-DQ1 can be found over a vast region and is in apparent selective disequilibrium.

[edit] Serotype

B7 serotype recognition of Some HLA B*07 allele-group gene products[2]
B*07 B7 Sample
allele  %  % size (N)
0702 98 10841


HLA B*0702 frequencies
freq
ref. Population (%)
[3] Ireland South 17.6
[3] Ireland Northern 17.3
[3] Australia New South Wales 12.0
[3] Croatia 9.7
[3] Azores Santa Maria and Sao Miguel 9.0
[3] Cameroon Beti 8.6
[3] Saudi Arabia Guraiat and Hail 8.3
[3] Azores Central Islands 8.0
[3] France South East 7.2
[3] Cameroon Bamileke 7.1
[3] Portugal Centre 7.0
[3] Italy North pop 1 6.7
[3] Japan Central 6.5
[3] Czech Republic 6.1
[3] Uganda Kampala 5.9
[3] Mali Bandiagara 5.8
[3] Senegal Niokholo Mandenka 5.8
[3] India Mumbai Marathas 4.9
[3] Zambia Lusaka 4.6
[3] Zimbabwe Harare Shona 4.6
[3] South Africian Natal Zulu 4.5
[3] Romanian 3.7
[3] South Korea (3) 3.5
[3] China Beijing Shijiazhuang Tianjian Han 3.4
[3] India North Delhi 3.3
[3] Kenya Luo 2.5
[3] China Guangzhou Han 2.4
[3] Mexico Chihuahua State Tarahumara 2.3
[3] Sudanese 2.3
[3] Singapore Javanese Indonesians 2.0
[3] Spain Eastern Andalusia Gipsy 2.0
[3] New Caledonia 1.9
[3] Oman 1.7
[3] USA Alaska Yupik Natives 1.6
[3] China Beijing 1.5
[3] Tunisia 1.5
[3] Argentina Toba Rosario 1.2
[3] Singapore Chinese Han 1.2
[3] USA Arizona Pima 1.1
[3] American Samoa 1.0
[3] Japan Ainu Hokkaido 1.0
[3] Kenya Nandi 1.0
[3] Portugal South 1.0
[3] Singapore Riau Malay 1.0
[3] Singapore Thai 1.0


[edit] References

  1. ^ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720. 
  2. ^ derived from IMGT/HLA
  3. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660. 
v • d • e
HLA-B serotypes and allele groups

HLA-B · B5 (B51 · B52) · B7 · B8 · B12 (B44 · B45) · B13 · B14 (B64 · B65) · B15 (B62 · B63 · B70 · B71 · B75 · B76 · B77) · B16 (B38 · B39) · B17 (B57 · B58) · B18 · B21 (B49 · B50) · B22 (B54 · B55 · B56) · B27 · B35 · B37 · B40 (B60 · B61) · B41 · B42 · B46 · B47 · B48 · B53 · B59 · B67 · B73 · B78 · B81 · B*82 · B*83