HLA-B67

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major histocompatibility complex (human), class I, B67
Alleles B*6701
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*6701
Locus chr.6 6p21.31

HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products.[1] B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim (Taiwan, Japan, Korea, Coastal Siberia), and B7, B22, or B27.[2] (For terminology help see: HLA-serotype tutorial)

[edit] Serotype

B67 Serotype recognition of the B*67 allele-group gene products[3]
B*67 B67 Other Sample
allele  %  % size (N)
6701 32 62 81


[edit] By allele

Regions of higher B*6701 frequency
Japan
Taiwan
Heilongjiang
province, China
(Harbin city)
Beijing
China
Shandong
peninsula
HLA B*6701 frequencies
freq
ref. Population (%)
[4] Osaka Region (Japan) 2.6
[4] Hakka (Taiwan) 1.8
[4] Japan (5) 1.7
[4] Harbin Man (China) 1.7
[4] Beijing (China) 1.5
[4] Linqu (Shandong, China) 1.1
[4] Siraya (Taiwan) 1.0
[4] Portugal South 1.0
[4] Oold (Mongolia) 1.0
[4] American Samoa 1.0
[4] Pazeh (Taiwan) 0.9
[4] South Korea (3) 0.9
[4] N. Korean (Harbin,China) 0.8
[4] Arratia Basque (Spain) 0.6
[4] Tarialan Khoton (Mongolia) 0.6
[4] Shanghai (China) 0.6
[4] Natal Zulu (South African) 0.5
[4] Yunnan Han (China) 0.5
[4] Turkey 0.4
[4] Southern Han (China) 0.4
[4] Tuva (Russia) 0.3
[4] Chinese (Hong Kong , China) 0.1

[edit] References

  1. ^ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720. 
  2. ^ Little AM, Domena JD, Hildebrand WH, et al (1994). "HLA-B67: a member of the HLA-B16 family that expresses the ME1 epitope". Tissue Antigens 43 (1): 38–43. PMID 7517584. 
  3. ^ derived from IMGT/HLA
  4. ^ a b c d e f g h i j k l m n o p q r s t u v Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660. 
v • d • e
HLA-B serotypes and allele groups

HLA-B · B5 (B51 · B52) · B7 · B8 · B12 (B44 · B45) · B13 · B14 (B64 · B65) · B15 (B62 · B63 · B70 · B71 · B75 · B76 · B77) · B16 (B38 · B39) · B17 (B57 · B58) · B18 · B21 (B49 · B50) · B22 (B54 · B55 · B56) · B27 · B35 · B37 · B40 (B60 · B61) · B41 · B42 · B46 · B47 · B48 · B53 · B59 · B67 · B73 · B78 · B81 · B*82 · B*83