HLA-B58

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major histocompatibility complex (human), class I, B58
Alleles B*5801, B*5802
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*5801
B*5802
Locus chr.6 6p21.31

HLA-B58 (B58) is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57.[1] The serotype identifies the more common HLA-B*58 gene products.[2] (For terminology help see: HLA-serotype tutorial)

[edit] Serotype

B58 and B17 serotype recognition of some more common HLA B*58 alleles[3]
B*58 B58 B17 Sample
allele  %  % size (N)
5801 79 4 2096
5802 72 3 837


[edit] Allele distribution

HLA B*5801 frequencies
freq
ref. Population (%)
[4] Cameroon Pygmy Baka 15.0
[4] India Khandesh Pawra 15.0
[4] Cameroon Sawa 11.5
[4] Taiwan Hakka 10.9
[4] Kenya Nandi 10.0
[4] India West Bhils 9.0
[4] China South Han 8.9
[4] China Inner Mongolia 8.8
[4] India North Delhi 8.8
[4] Thailand Northeast 8.4
[4] Guinea Bissau 7.8
[4] Thailand 7.7
[4] India Mumbai Marathas 7.4
[4] India Andhra Pradesh Golla 7.2
[4] Kenya Luo 7.0
[4] Senegal Niokholo Mandenka 6.9
[4] India New Delhi 6.8
[4] Oman 6.8
[4] Russia Tuva (2) 6.7
[4] South Korea (3) 6.5
[4] Italy Sardinia (3) 6.4
[4] Burkina Faso Fulani 6.1
[4] Taiwan Siraya 5.9
[4] India North Hindus 5.8
[4] Burkina Faso Mossi 5.7
[4] Cameroon Yaounde 5.4
[4] Cameroon Bamileke 5.2
[4] Singapore Riau Malay 5.0
[4] Saudi Arabia Guraiat and Hail 4.6
[4] France Corsica 4.5
[4] Sudanese 4.5
[4] Zimbabwe Harare Shona 4.4
[4] Burkina Faso Rimaibe 4.3
[4] Iran Baloch 4.0
[4] South Africian Natal Zulu 4.0
[4] Tunisia 4.0
[4] Uganda Kampala 4.0
[4] Cameroon Beti 3.7
[4] Tunisia Ghannouch 3.7
[4] Taiwan Pazeh 3.6
[4] Tunisia Tunis 3.4
[4] Italy North (1) 3.3
[4] Israel Ashkenazi and Non Ashkenazi Jews 3.2
[4] India West Coast Parsis 3.0
[4] China North Han 2.9
[4] Ivory Coast Akan Adiopodoume 2.3
[4] Mali Bandiagara 2.2
[4] Mexico Zaptotec Oaxaca 2.2
[4] South Africa Natal Tamil 2.0
[4] China Yunnan Nu 1.9
[4] Bulgaria 1.8
[4] China Tibet Autonomous Region Tibetans 1.6
[4] France South East 1.6
[4] Israel Arab Druse 1.5
[4] Czech Republic 1.4
[4] Georgia Tibilisi Georgians 1.4
[4] Jordan Amman 1.4
[4] Morocco Nador Metalsa (berber) 1.4
[4] Croatia 1.3
[4] Romanian 1.3
[4] Spain Eastern Andalusia 1.2
[4] Australian Aborigine Cape York Peninsula 1.0
B*5802
[4] Cameroon Bamileke 14.3
[4] Kenya Luo 12.5
[4] Cameroon Yaounde 10.9
[4] Cameroon Pygmy Baka 10.0
[4] Cameroon Beti 9.8
[4] Kenya Nandi 8.5
[4] South Africian Natal Zulu 8.5
[4] Cameroon Sawa 7.7
[4] Zimbabwe Harare Shona 6.4
[4] Cape Verde Northwestern Islands 5.6
[4] Uganda Kampala 4.4
[4] Central Africa Republic Mbenzele Pygmy 4.0
[4] Zambia Lusaka 2.3
[4] Iran Baloch 1.0
[4] Tunisia 1.0

[edit] References

  1. ^ Ways JP, Coppin HL, Parham P (1985). "The complete primary structure of HLA-Bw58". J. Biol. Chem. 260 (22): 11924–33. PMID 2995352. 
  2. ^ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720. 
  3. ^ derived from IMGT/HLA
  4. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi bj bk bl bm bn bo bp bq br bs bt bu bv bw bx by Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. PMID 12753660. 
v • d • e
HLA-B serotypes and allele groups

HLA-B · B5 (B51 · B52) · B7 · B8 · B12 (B44 · B45) · B13 · B14 (B64 · B65) · B15 (B62 · B63 · B70 · B71 · B75 · B76 · B77) · B16 (B38 · B39) · B17 (B57 · B58) · B18 · B21 (B49 · B50) · B22 (B54 · B55 · B56) · B27 · B35 · B37 · B40 (B60 · B61) · B41 · B42 · B46 · B47 · B48 · B53 · B59 · B67 · B73 · B78 · B81 · B*82 · B*83